Abstract
Objectives: To examine by race how frequently the data after radical prostatectomy translates into a substantial change in prognosis. Many nomograms exist to predict the survival outcomes using the pretreatment clinical parameters and post-treatment pathologic parameters. Race might be an important factor affecting their predictive ability. Methods: Kattan nomograms were used to calculate the pretreatment and post-radical prostatectomy 5-year progression-free probability for each patient. The difference between the nomogram scores was used to divide the patients into 3 groups. A decrease in probability of ≥15 percentage points was classified as a significant increase in the probability of recurrence, an increase of ≥15 points was classified as a significant decrease in the probability of recurrence, and an absolute change of <15 points was considered no significant change. Results: The data from 1709 (132 black and 1577 white) men were analyzed. Among the black men, 26.5% had an increase in the probability of recurrence, 57.6% had no change, and 15.9% had a decrease in the probability of recurrence. Among the white men, 13.8% had an increase in the probability of recurrence, 64.5% had no change, and 21.7% had a decrease in the probability of recurrence. Black men were twice as likely to have a significant increase in the probability of recurrence postoperatively compared with white men after adjusting for preoperative prostate-specific antigen level, clinical stage, and biopsy Gleason sum (odds ratio 2.0, 95% confidence interval 1.3-3.1, P = .002). Conclusions: These data could assist clinicians when counseling black men regarding their treatment options according to their preoperative risk profile.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 660-664 |
| Number of pages | 5 |
| Journal | Urology |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2009 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Urology
Cite this
Significant Change in Predicted Risk of Biochemical Recurrence After Radical Prostatectomy More Common in Black Than in White Men. / Laudano, Melissa A.; Badani, Ketan K.; McCann, Tara R.; Mann, Mark J.; Ritch, Chad; Desai, Manisha; Benson, Mitchell C.; McKiernan, James M.
In: Urology, Vol. 74, No. 3, 09.2009, p. 660-664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significant Change in Predicted Risk of Biochemical Recurrence After Radical Prostatectomy More Common in Black Than in White Men
AU - Laudano, Melissa A.
AU - Badani, Ketan K.
AU - McCann, Tara R.
AU - Mann, Mark J.
AU - Ritch, Chad
AU - Desai, Manisha
AU - Benson, Mitchell C.
AU - McKiernan, James M.
PY - 2009/9
Y1 - 2009/9
N2 - Objectives: To examine by race how frequently the data after radical prostatectomy translates into a substantial change in prognosis. Many nomograms exist to predict the survival outcomes using the pretreatment clinical parameters and post-treatment pathologic parameters. Race might be an important factor affecting their predictive ability. Methods: Kattan nomograms were used to calculate the pretreatment and post-radical prostatectomy 5-year progression-free probability for each patient. The difference between the nomogram scores was used to divide the patients into 3 groups. A decrease in probability of ≥15 percentage points was classified as a significant increase in the probability of recurrence, an increase of ≥15 points was classified as a significant decrease in the probability of recurrence, and an absolute change of <15 points was considered no significant change. Results: The data from 1709 (132 black and 1577 white) men were analyzed. Among the black men, 26.5% had an increase in the probability of recurrence, 57.6% had no change, and 15.9% had a decrease in the probability of recurrence. Among the white men, 13.8% had an increase in the probability of recurrence, 64.5% had no change, and 21.7% had a decrease in the probability of recurrence. Black men were twice as likely to have a significant increase in the probability of recurrence postoperatively compared with white men after adjusting for preoperative prostate-specific antigen level, clinical stage, and biopsy Gleason sum (odds ratio 2.0, 95% confidence interval 1.3-3.1, P = .002). Conclusions: These data could assist clinicians when counseling black men regarding their treatment options according to their preoperative risk profile.
AB - Objectives: To examine by race how frequently the data after radical prostatectomy translates into a substantial change in prognosis. Many nomograms exist to predict the survival outcomes using the pretreatment clinical parameters and post-treatment pathologic parameters. Race might be an important factor affecting their predictive ability. Methods: Kattan nomograms were used to calculate the pretreatment and post-radical prostatectomy 5-year progression-free probability for each patient. The difference between the nomogram scores was used to divide the patients into 3 groups. A decrease in probability of ≥15 percentage points was classified as a significant increase in the probability of recurrence, an increase of ≥15 points was classified as a significant decrease in the probability of recurrence, and an absolute change of <15 points was considered no significant change. Results: The data from 1709 (132 black and 1577 white) men were analyzed. Among the black men, 26.5% had an increase in the probability of recurrence, 57.6% had no change, and 15.9% had a decrease in the probability of recurrence. Among the white men, 13.8% had an increase in the probability of recurrence, 64.5% had no change, and 21.7% had a decrease in the probability of recurrence. Black men were twice as likely to have a significant increase in the probability of recurrence postoperatively compared with white men after adjusting for preoperative prostate-specific antigen level, clinical stage, and biopsy Gleason sum (odds ratio 2.0, 95% confidence interval 1.3-3.1, P = .002). Conclusions: These data could assist clinicians when counseling black men regarding their treatment options according to their preoperative risk profile.
UR - http://www.scopus.com/inward/record.url?scp=69249210986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69249210986&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2008.10.075
DO - 10.1016/j.urology.2008.10.075
M3 - Article
C2 - 19589568
AN - SCOPUS:69249210986
VL - 74
SP - 660
EP - 664
JO - Urology
JF - Urology
SN - 0090-4295
IS - 3
ER -