Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy

M. Craig Hall, Patricia Troncoso, Alan Pollack, Haiyen Ye Zhau, Gunar K. Zagars, Leland W K Chung, Andrew C. von Eschenbach

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Objectives.: To determine the prognostic significance of microvessel density(a measure of tumor angiogenesis) in comparison with other prognostic factors for patients with clinically localized prostatic carcinoma treated with external beam radiotherapy. Methods.: Microvessel density was quantified within the initial invasive carcinoma from the diagnostic transurethral resection specimen of 25 patients with a mean follow-up of 44 months. Microvessels were identified by immunohistochemical staining of endothelial cells for factor Vlll-related antigen in formalin-fixed, paraffin-embedded tissue. Microvessels were counted in a ×200 field (0.754 mm2) in the area of maximal angiogenesis. Results.: Microvessel density correlated with several pretreatment prognostic factors,including prostate-specific antigen (PSA) (p < 0.0001), tumor grade (p = 0.006), and ploidy (p = 0.016). The degree of tumor angiogenesis also correlated with outcome following external beam radiotherapy. The mean microvessel count in the nine tumors from patients who failed radiotherapy (ie, had rising PSA and/or clinical relapse) was 97.0±33.6 (± SD) per ×200 field compared with 46.1 ± 17.1 for the 16 patients with no evidence of failure (p < 0.0001). Increased microvessel density was also associated with a significantly worse actuarial outcome at 4 years using either biochemical relapse (rising PSA) or a composite endpoint of rising PSA or clinical relapse (p = 0.0003). Conclusions.: The intratumoral quantification of tumor angiogenesis may prove valuableas a prognostic indicator in patients with clinically localized prostate cancer treated with radiotherapy.

Original languageEnglish
Pages (from-to)869-875
Number of pages7
JournalUrology
Volume44
Issue number6
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Microvessels
Prostate
Radiotherapy
Carcinoma
Prostate-Specific Antigen
Neoplasms
Recurrence
Ploidies
Paraffin
Formaldehyde
Prostatic Neoplasms
Endothelial Cells
Staining and Labeling
Antigens

ASJC Scopus subject areas

  • Urology

Cite this

Craig Hall, M., Troncoso, P., Pollack, A., Ye Zhau, H., Zagars, G. K., Chung, L. W. K., & von Eschenbach, A. C. (1994). Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy. Urology, 44(6), 869-875. https://doi.org/10.1016/S0090-4295(94)80173-8

Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy. / Craig Hall, M.; Troncoso, Patricia; Pollack, Alan; Ye Zhau, Haiyen; Zagars, Gunar K.; Chung, Leland W K; von Eschenbach, Andrew C.

In: Urology, Vol. 44, No. 6, 01.01.1994, p. 869-875.

Research output: Contribution to journalArticle

Craig Hall, M, Troncoso, P, Pollack, A, Ye Zhau, H, Zagars, GK, Chung, LWK & von Eschenbach, AC 1994, 'Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy', Urology, vol. 44, no. 6, pp. 869-875. https://doi.org/10.1016/S0090-4295(94)80173-8
Craig Hall, M. ; Troncoso, Patricia ; Pollack, Alan ; Ye Zhau, Haiyen ; Zagars, Gunar K. ; Chung, Leland W K ; von Eschenbach, Andrew C. / Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy. In: Urology. 1994 ; Vol. 44, No. 6. pp. 869-875.
@article{eb69056594a04d8c830a73b70677eeac,
title = "Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy",
abstract = "Objectives.: To determine the prognostic significance of microvessel density(a measure of tumor angiogenesis) in comparison with other prognostic factors for patients with clinically localized prostatic carcinoma treated with external beam radiotherapy. Methods.: Microvessel density was quantified within the initial invasive carcinoma from the diagnostic transurethral resection specimen of 25 patients with a mean follow-up of 44 months. Microvessels were identified by immunohistochemical staining of endothelial cells for factor Vlll-related antigen in formalin-fixed, paraffin-embedded tissue. Microvessels were counted in a ×200 field (0.754 mm2) in the area of maximal angiogenesis. Results.: Microvessel density correlated with several pretreatment prognostic factors,including prostate-specific antigen (PSA) (p < 0.0001), tumor grade (p = 0.006), and ploidy (p = 0.016). The degree of tumor angiogenesis also correlated with outcome following external beam radiotherapy. The mean microvessel count in the nine tumors from patients who failed radiotherapy (ie, had rising PSA and/or clinical relapse) was 97.0±33.6 (± SD) per ×200 field compared with 46.1 ± 17.1 for the 16 patients with no evidence of failure (p < 0.0001). Increased microvessel density was also associated with a significantly worse actuarial outcome at 4 years using either biochemical relapse (rising PSA) or a composite endpoint of rising PSA or clinical relapse (p = 0.0003). Conclusions.: The intratumoral quantification of tumor angiogenesis may prove valuableas a prognostic indicator in patients with clinically localized prostate cancer treated with radiotherapy.",
author = "{Craig Hall}, M. and Patricia Troncoso and Alan Pollack and {Ye Zhau}, Haiyen and Zagars, {Gunar K.} and Chung, {Leland W K} and {von Eschenbach}, {Andrew C.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1016/S0090-4295(94)80173-8",
language = "English",
volume = "44",
pages = "869--875",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy

AU - Craig Hall, M.

AU - Troncoso, Patricia

AU - Pollack, Alan

AU - Ye Zhau, Haiyen

AU - Zagars, Gunar K.

AU - Chung, Leland W K

AU - von Eschenbach, Andrew C.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Objectives.: To determine the prognostic significance of microvessel density(a measure of tumor angiogenesis) in comparison with other prognostic factors for patients with clinically localized prostatic carcinoma treated with external beam radiotherapy. Methods.: Microvessel density was quantified within the initial invasive carcinoma from the diagnostic transurethral resection specimen of 25 patients with a mean follow-up of 44 months. Microvessels were identified by immunohistochemical staining of endothelial cells for factor Vlll-related antigen in formalin-fixed, paraffin-embedded tissue. Microvessels were counted in a ×200 field (0.754 mm2) in the area of maximal angiogenesis. Results.: Microvessel density correlated with several pretreatment prognostic factors,including prostate-specific antigen (PSA) (p < 0.0001), tumor grade (p = 0.006), and ploidy (p = 0.016). The degree of tumor angiogenesis also correlated with outcome following external beam radiotherapy. The mean microvessel count in the nine tumors from patients who failed radiotherapy (ie, had rising PSA and/or clinical relapse) was 97.0±33.6 (± SD) per ×200 field compared with 46.1 ± 17.1 for the 16 patients with no evidence of failure (p < 0.0001). Increased microvessel density was also associated with a significantly worse actuarial outcome at 4 years using either biochemical relapse (rising PSA) or a composite endpoint of rising PSA or clinical relapse (p = 0.0003). Conclusions.: The intratumoral quantification of tumor angiogenesis may prove valuableas a prognostic indicator in patients with clinically localized prostate cancer treated with radiotherapy.

AB - Objectives.: To determine the prognostic significance of microvessel density(a measure of tumor angiogenesis) in comparison with other prognostic factors for patients with clinically localized prostatic carcinoma treated with external beam radiotherapy. Methods.: Microvessel density was quantified within the initial invasive carcinoma from the diagnostic transurethral resection specimen of 25 patients with a mean follow-up of 44 months. Microvessels were identified by immunohistochemical staining of endothelial cells for factor Vlll-related antigen in formalin-fixed, paraffin-embedded tissue. Microvessels were counted in a ×200 field (0.754 mm2) in the area of maximal angiogenesis. Results.: Microvessel density correlated with several pretreatment prognostic factors,including prostate-specific antigen (PSA) (p < 0.0001), tumor grade (p = 0.006), and ploidy (p = 0.016). The degree of tumor angiogenesis also correlated with outcome following external beam radiotherapy. The mean microvessel count in the nine tumors from patients who failed radiotherapy (ie, had rising PSA and/or clinical relapse) was 97.0±33.6 (± SD) per ×200 field compared with 46.1 ± 17.1 for the 16 patients with no evidence of failure (p < 0.0001). Increased microvessel density was also associated with a significantly worse actuarial outcome at 4 years using either biochemical relapse (rising PSA) or a composite endpoint of rising PSA or clinical relapse (p = 0.0003). Conclusions.: The intratumoral quantification of tumor angiogenesis may prove valuableas a prognostic indicator in patients with clinically localized prostate cancer treated with radiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0028592165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028592165&partnerID=8YFLogxK

U2 - 10.1016/S0090-4295(94)80173-8

DO - 10.1016/S0090-4295(94)80173-8

M3 - Article

C2 - 7527168

AN - SCOPUS:0028592165

VL - 44

SP - 869

EP - 875

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -