Significance of preoperative PSA velocity in men with low serum PSA and normal DRE

Danil V. Makarov, Stacy Loeb, Ahmed Magheli, Kevin Zhao, Elizabeth Humphreys, Mark L. Gonzalgo, Alan W. Partin, Misop Han

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives: A PSA velocity (PSAV)>0.35 ng/ml/year approximately 10-15 years prior to diagnosis is associated with a greater risk of lethal prostate cancer. Some have recommended that a PSAV>0.35 ng/ml/year should prompt a prostate biopsy in men with a low serum PSA (<4 ng/ml) and benign DRE. However, less is known about the utility of this PSAV cutpoint for the prediction of treatment outcomes among men undergoing radical prostatectomy (RP). Methods: Between 1992 and 2007, 339 men underwent RP at our institution with a preoperative PSA <4 ng/ml, benign DRE, and multiple preoperative PSA measurements. PSAV was calculated by linear regression analysis using all PSA values within 18 months prior to diagnosis. Kaplan-Meier survival analysis was performed, and biochemical progression rates were compared between PSAV strata using the log-rank test. Results: The preoperative PSAV was>0. 35 ng/ml/year in 124 (36.6%) of 339 men. Although there were no significant differences in clinico-pathological characteristics based upon PSAV, men with a PSAV>0.35 ng/ml/year were significantly more likely to experience biochemical progression after RP at a median follow-up of 4 years (P = 0.022). Conclusions: In this low-risk population with a preoperative PSA <4 ng/ml and benign DRE, approximately 1/3 had a preoperative PSAV>0.35 ng/ml/year. Physicians should carefully monitor men with a preoperative PSA>0.35 ng/ml/year as they are at increased risk of biochemical progression following RP.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalWorld journal of urology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Keywords

  • Gleason score
  • PSA
  • PSAV
  • Pathologic stage
  • Prostate cancer
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology

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    Makarov, D. V., Loeb, S., Magheli, A., Zhao, K., Humphreys, E., Gonzalgo, M. L., Partin, A. W., & Han, M. (2011). Significance of preoperative PSA velocity in men with low serum PSA and normal DRE. World journal of urology, 29(1), 11-14. https://doi.org/10.1007/s00345-010-0625-4