Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast

Yasser M. El-Gohary, Ghada Metwally, Reda S. Saad, Morton J. Robinson, Thomas Mesko, Robert J. Poppiti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the significance of periductal lymphatic and blood vascular densities in intraductal carcinomas (IDC) of the breast. Thirty five cases of pure IDC treated by partial or total mastectomy were reviewed. Seven cases with normal breast tissue and 48 cases of invasive breast carcinoma were included as controls. All cases were immunostained with D2-40 and CD31. Positively stained microvessels were counted in densely vascular/lymphatic foci (hot spots) at 400× (=0.17 mm 2) in the periductal areas. IDC without comedonecrosis showed a mean periductal D2-40 lymphatic microvessel density (LMD) of 5.8 ± 5 (range 0-18), and a CD31 microvessel density (MD) of 14 ± 8.9 (range 1-40). IDC with comedonecrosis showed periductal D2-40 LMD of 8.4 ± 3.8 (range 4-18), and a CD31 MD of 24.3 ± 7.6 (range 14-40). There was a significant difference between periductal D2-40 LMD and CD31 MD counts in IDC with and without comedonecrosis. There was a positive correlation of periductal D2-40 LMD and CD31 MD counts with high nuclear grade (r = 0.39 and 0.56) of IDC as well as with the presence of comedonecrosis (r = 0.49 and 0.59). Both D2-40 LMD and CD31 MD did not correlate significantly with tumor size, estrogen status, or progesterone status. As IDC with comedonecrosis and/or high nuclear grade has a worse prognosis than IDC without comedonecrosis and/or with low nuclear grade, it appears that lymphatic and blood vascular density evaluated by D2-40 and CD31, respectively, are independent prognostic indicators for patients with IDC of the breast and may be an indicator of early or unrecognized invasion or regression.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalBreast Journal
Volume15
Issue number3
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Microvessels
Blood Vessels
Breast
Simple Mastectomy
Segmental Mastectomy
Progesterone
Estrogens
Breast Neoplasms

Keywords

  • Breast
  • Comedonecrosis
  • Intraductal carcinoma
  • Lymphatic
  • Microvessel density

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology
  • Surgery

Cite this

El-Gohary, Y. M., Metwally, G., Saad, R. S., Robinson, M. J., Mesko, T., & Poppiti, R. J. (2009). Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast. Breast Journal, 15(3), 261-267. https://doi.org/10.1111/j.1524-4741.2009.00715.x

Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast. / El-Gohary, Yasser M.; Metwally, Ghada; Saad, Reda S.; Robinson, Morton J.; Mesko, Thomas; Poppiti, Robert J.

In: Breast Journal, Vol. 15, No. 3, 01.05.2009, p. 261-267.

Research output: Contribution to journalArticle

El-Gohary, YM, Metwally, G, Saad, RS, Robinson, MJ, Mesko, T & Poppiti, RJ 2009, 'Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast', Breast Journal, vol. 15, no. 3, pp. 261-267. https://doi.org/10.1111/j.1524-4741.2009.00715.x
El-Gohary, Yasser M. ; Metwally, Ghada ; Saad, Reda S. ; Robinson, Morton J. ; Mesko, Thomas ; Poppiti, Robert J. / Significance of periductal lymphatic and blood vascular densities in intraductal carcinoma of the breast. In: Breast Journal. 2009 ; Vol. 15, No. 3. pp. 261-267.
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abstract = "We investigated the significance of periductal lymphatic and blood vascular densities in intraductal carcinomas (IDC) of the breast. Thirty five cases of pure IDC treated by partial or total mastectomy were reviewed. Seven cases with normal breast tissue and 48 cases of invasive breast carcinoma were included as controls. All cases were immunostained with D2-40 and CD31. Positively stained microvessels were counted in densely vascular/lymphatic foci (hot spots) at 400× (=0.17 mm 2) in the periductal areas. IDC without comedonecrosis showed a mean periductal D2-40 lymphatic microvessel density (LMD) of 5.8 ± 5 (range 0-18), and a CD31 microvessel density (MD) of 14 ± 8.9 (range 1-40). IDC with comedonecrosis showed periductal D2-40 LMD of 8.4 ± 3.8 (range 4-18), and a CD31 MD of 24.3 ± 7.6 (range 14-40). There was a significant difference between periductal D2-40 LMD and CD31 MD counts in IDC with and without comedonecrosis. There was a positive correlation of periductal D2-40 LMD and CD31 MD counts with high nuclear grade (r = 0.39 and 0.56) of IDC as well as with the presence of comedonecrosis (r = 0.49 and 0.59). Both D2-40 LMD and CD31 MD did not correlate significantly with tumor size, estrogen status, or progesterone status. As IDC with comedonecrosis and/or high nuclear grade has a worse prognosis than IDC without comedonecrosis and/or with low nuclear grade, it appears that lymphatic and blood vascular density evaluated by D2-40 and CD31, respectively, are independent prognostic indicators for patients with IDC of the breast and may be an indicator of early or unrecognized invasion or regression.",
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