Significance of intraperitoneal cytology in patients undergoing radical hysterectomy

Ricardo Estape, Roberto Angioli, Felicia Wagman, Marilu Madrigal, Mike Janicek, Parvin Ganjei-Azar, Manuel Penalver, Hervy Averette

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The incidence and prognostic significance of positive intraperitoneal cytology taken during a radical hysterectomy was reviewed. A prospective study looking at intraperitoneal cytology was conducted by using 400 consecutive radical hysterectomies from January 1988 through June 1996. All selected patients had peritoneal washings performed prior to a radical hysterectomy with pelvic and para-aortic lymphadenectomy. A single pathologist reviewed all cytological and histologic specimens. A total of 400 patients were included in the study. Only 7 of 400 (1.8%) had positive intraperitoneal cytology. Four had squamous cell cancer and 3 had adenocarcinoma. Five had stage IB cervical cancer and the remainder were stage IIA. Three had positive nodes. Six of 7 had tumor size greater than 3 cm. Three of 7 had >50% invasion and 2 of 7 had lymphovascular space invasion. No other risk factors were present in these specimens. Six of 7 recurred within 18 months of surgery. Recurrences were local or retroperitoneal; none were upper abdomen or intraperitoneal. The incidence of positive peritoneal cytology during radical hysterectomy is 1.8%. The cost of these cytology specimens did not offer an advantage to the current surgical- pathological factors used to determine prognosis and adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalGynecologic oncology
Issue number2
StatePublished - Feb 1998

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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