Abstract
Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2073-2084 |
| Number of pages | 12 |
| Journal | Gastroenterology |
| Volume | 156 |
| Issue number | 7 |
| DOIs | |
| State | Published - May 1 2019 |
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Keywords
- Cancer Stem Cells
- Pancreatic Cancer Associated Fibroblasts
- Pancreatic Cellular Plasticity
- Signaling Crosstalk
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis. / Crawford, Howard C.; Pasca di Magliano, Marina; Banerjee, Sulagna.
In: Gastroenterology, Vol. 156, No. 7, 01.05.2019, p. 2073-2084.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis
AU - Crawford, Howard C.
AU - Pasca di Magliano, Marina
AU - Banerjee, Sulagna
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.
AB - Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.
KW - Cancer Stem Cells
KW - Pancreatic Cancer Associated Fibroblasts
KW - Pancreatic Cellular Plasticity
KW - Signaling Crosstalk
UR - http://www.scopus.com/inward/record.url?scp=85064571824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064571824&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2018.12.042
DO - 10.1053/j.gastro.2018.12.042
M3 - Article
C2 - 30716326
AN - SCOPUS:85064571824
VL - 156
SP - 2073
EP - 2084
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 7
ER -