Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis

Howard C. Crawford, Marina Pasca di Magliano, Sulagna Banerjee

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.

Original languageEnglish (US)
Pages (from-to)2073-2084
Number of pages12
JournalGastroenterology
Volume156
Issue number7
DOIs
StatePublished - May 2019

Keywords

  • Cancer Stem Cells
  • Pancreatic Cancer Associated Fibroblasts
  • Pancreatic Cellular Plasticity
  • Signaling Crosstalk

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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