Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis

Howard C. Crawford; Marina Pasca di Magliano; Sulagna Banerjee

doi:10.1053/j.gastro.2018.12.042

Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis

Howard C. Crawford, Marina Pasca di Magliano, Sulagna Banerjee

Surgery

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.

Original language	English (US)
Pages (from-to)	2073-2084
Number of pages	12
Journal	Gastroenterology
Volume	156
Issue number	7
DOIs	https://doi.org/10.1053/j.gastro.2018.12.042
State	Published - May 2019

Keywords

Cancer Stem Cells
Pancreatic Cancer Associated Fibroblasts
Pancreatic Cellular Plasticity
Signaling Crosstalk

ASJC Scopus subject areas

Hepatology
Gastroenterology

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abstract = "Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.",

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Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis

Abstract

Keywords

ASJC Scopus subject areas

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