Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

Rahul Mittal, Luca H. Debs, Desiree Nguyen, Amit P. Patel, M'hamed Grati, Jeenu Mittal, Denise Yan, Adrien Eshraghi, Xue Z Liu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ear is a sensitive organ involved in hearing and balance function. The complex signaling network in the auditory system plays a crucial role in maintaining normal physiological function of the ear. The inner ear comprises a variety of host signaling pathways working in synergy to deliver clear sensory messages. Any disruption, as minor as it can be, has the potential to affect this finely tuned system with temporary or permanent sequelae including vestibular deficits and hearing loss. Mutations linked to auditory symptoms, whether inherited or acquired, are being actively researched for ways to reverse, silence, or suppress them. In this article, we discuss recent advancements in understanding the pathways involved in auditory system signaling, from hair cell development through transmission to cortical centers. Our review discusses Notch and Wnt signaling, cell to cell communication through connexin and pannexin channels, and the detrimental effects of reactive oxygen species on the auditory system. There has been an increased interest in the auditory community to explore the signaling system in the ear for hair cell regeneration. Understanding signaling pathways in the auditory system will pave the way for the novel avenues to regenerate sensory hair cells and restore hearing function.

Original languageEnglish (US)
JournalJournal of Cellular Physiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Audition
Hearing
Regeneration
Cells
Ear
Auditory Pathways
Connexins
Cell signaling
Inner Ear
Hearing Loss
Cell Communication
Reactive Oxygen Species
Mutation
Communication

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Signaling in the Auditory System : Implications in Hair Cell Regeneration and Hearing Function. / Mittal, Rahul; Debs, Luca H.; Nguyen, Desiree; Patel, Amit P.; Grati, M'hamed; Mittal, Jeenu; Yan, Denise; Eshraghi, Adrien; Liu, Xue Z.

In: Journal of Cellular Physiology, 2017.

Research output: Contribution to journalArticle

Mittal, Rahul ; Debs, Luca H. ; Nguyen, Desiree ; Patel, Amit P. ; Grati, M'hamed ; Mittal, Jeenu ; Yan, Denise ; Eshraghi, Adrien ; Liu, Xue Z. / Signaling in the Auditory System : Implications in Hair Cell Regeneration and Hearing Function. In: Journal of Cellular Physiology. 2017.
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