Signal transduction in podocytes - Spotlight on receptor tyrosine kinases

Jochen Reiser, Sanja Sever, Christian H Faul

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The mammalian kidney filtration barrier is a complex multicellular, multicomponent structure that maintains homeostasis by regulating electrolytes, acid-base balance, and blood pressure (via maintenance of salt and water balance). To perform these multiple functions, podocytes - an important component of the filtration apparatus - must process a series of intercellular signals. Integrating these signals with diverse cellular responses enables a coordinated response to various conditions. Although mature podocytes are terminally differentiated and cannot proliferate, they are able to respond to growth factors. It is possible that the initial response of podocytes to growth factors is beneficial and protective, and might include the induction of hypertrophic cell growth. However, extended and/or uncontrolled growth factor signalling might be maladaptive and could result in the induction of apoptosis and podocyte loss. Growth factors signal via the activation of receptor tyrosine kinases (RTKs) on their target cells and around a quarter of the 58 RTK family members that are encoded in the human genome have been identified in podocytes. Pharmacological inhibitors of many RTKs exist and are currently used in experimental and clinical cancer therapy. The identification of pathological RTK-mediated signal transduction pathways in podocytes could provide a starting point for the development of novel therapies for glomerular disorders.

Original languageEnglish
Pages (from-to)104-115
Number of pages12
JournalNature Reviews Nephrology
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2014

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Podocytes
Receptor Protein-Tyrosine Kinases
Signal Transduction
Intercellular Signaling Peptides and Proteins
Acid-Base Equilibrium
Human Genome
Electrolytes
Homeostasis
Salts
Maintenance
Pharmacology
Apoptosis
Blood Pressure
Kidney
Water
Therapeutics
Growth
Neoplasms

ASJC Scopus subject areas

  • Nephrology

Cite this

Signal transduction in podocytes - Spotlight on receptor tyrosine kinases. / Reiser, Jochen; Sever, Sanja; Faul, Christian H.

In: Nature Reviews Nephrology, Vol. 10, No. 2, 01.02.2014, p. 104-115.

Research output: Contribution to journalArticle

Reiser, Jochen ; Sever, Sanja ; Faul, Christian H. / Signal transduction in podocytes - Spotlight on receptor tyrosine kinases. In: Nature Reviews Nephrology. 2014 ; Vol. 10, No. 2. pp. 104-115.
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