Signal transduction and information processing in mammalian taste buds

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

The molecular machinery for chemosensory transduction in taste buds has received considerable attention within the last decade. Consequently, we now know a great deal about sweet, bitter, and umami taste mechanisms and are gaining ground rapidly on salty and sour transduction. Sweet, bitter, and umami tastes are transduced by G-protein-coupled receptors. Salty taste may be transduced by epithelial Na channels similar to those found in renal tissues. Sour transduction appears to be initiated by intracellular acidification acting on acid-sensitive membrane proteins. Once a taste signal is generated in a taste cell, the subsequent steps involve secretion of neurotransmitters, including ATP and serotonin. It is now recognized that the cells responding to sweet, bitter, and umami taste stimuli do not possess synapses and instead secrete the neurotransmitter ATP via a novel mechanism not involving conventional vesicular exocytosis. ATP is believed to excite primary sensory afferent fibers that convey gustatory signals to the brain. In contrast, taste cells that do have synapses release serotonin in response to gustatory stimulation. The postsynaptic targets of serotonin have not yet been identified. Finally, ATP secreted from receptor cells also acts on neighboring taste cells to stimulate their release of serotonin. This suggests that there is important information processing and signal coding taking place in the mammalian taste bud after gustatory stimulation.

Original languageEnglish
Pages (from-to)759-776
Number of pages18
JournalPflugers Archiv European Journal of Physiology
Volume454
Issue number5
DOIs
StatePublished - Aug 1 2007

Fingerprint

Taste Buds
Signal transduction
Automatic Data Processing
Signal Transduction
Serotonin
Adenosine Triphosphate
Neurotransmitter Agents
Epithelial Sodium Channels
Acidification
G-Protein-Coupled Receptors
Machinery
Brain
Membrane Proteins
Tissue
Synapses
Acids
Fibers
Purinergic P2 Receptors
Exocytosis

Keywords

  • ATP
  • Bitter
  • Neurotransmitters
  • Salty
  • Serotonin
  • Sour
  • Sweet
  • Taste bud
  • Transduction
  • Umami

ASJC Scopus subject areas

  • Physiology

Cite this

Signal transduction and information processing in mammalian taste buds. / Roper, Stephen D.

In: Pflugers Archiv European Journal of Physiology, Vol. 454, No. 5, 01.08.2007, p. 759-776.

Research output: Contribution to journalArticle

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