Abstract
Background: Little is known about the national outcome of children and adults with sickle cell disease (SCD) given contemporary care. Procedure: We investigated the number of deaths, standardized crude and age-adjusted mortality rates, and causes of death among individuals with SCD across the United States during 1999-2009 according to death certificates by using a publicly available website (http://wonder.cdc.gov/). Data were compared to mortality during 1979-1998. Results: When compared to 1979-1998, mortality significantly decreased by 61% in infants <1 year of age, by 67% in children aged 1-4 years, and by 22-35% in children aged 5-19 years. After 19 years of age, mortality rates increased from 0.6 in the 15-19 year group to 1.4/100,000 in the 20-24 year group, corresponding to the transition period from pediatric to adult medical care, and this increase was similar during 1979-1998. Although the age groups with the highest mortality were 35-44 years for males and 45-54 years for females, there was a tendency for longer survival because there were more deaths among those individuals 55-74 years of age compared to previous years. For all individuals, the causes of deaths were cardiac disease (31.6%), respiratory (28.1%), renal (16.4%), infectious (14.4%), neurologic (11.9%), and gastrointestinal and hepatobiliary (9.2%) in nature. Cancer was the cause of death in <1%. Conclusion: Mortality during childhood has decreased significantly. However, the transition period from pediatric to adult care is critical. Risk-reduction, monitoring, and early treatment intervention of cardiovascular disease in adults is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 1482-1486 |
| Number of pages | 5 |
| Journal | Pediatric Blood and Cancer |
| Volume | 60 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2013 |
Fingerprint
Keywords
- Mortality
- Sickle cell disease
- Survival
- Transition
ASJC Scopus subject areas
- Oncology
- Pediatrics, Perinatology, and Child Health
- Hematology
Cite this
Sickle cell disease related mortality in the United States (1999-2009). / Hamideh, Dima; Alvarez, Ofelia A.
In: Pediatric Blood and Cancer, Vol. 60, No. 9, 01.09.2013, p. 1482-1486.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sickle cell disease related mortality in the United States (1999-2009)
AU - Hamideh, Dima
AU - Alvarez, Ofelia A
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Background: Little is known about the national outcome of children and adults with sickle cell disease (SCD) given contemporary care. Procedure: We investigated the number of deaths, standardized crude and age-adjusted mortality rates, and causes of death among individuals with SCD across the United States during 1999-2009 according to death certificates by using a publicly available website (http://wonder.cdc.gov/). Data were compared to mortality during 1979-1998. Results: When compared to 1979-1998, mortality significantly decreased by 61% in infants <1 year of age, by 67% in children aged 1-4 years, and by 22-35% in children aged 5-19 years. After 19 years of age, mortality rates increased from 0.6 in the 15-19 year group to 1.4/100,000 in the 20-24 year group, corresponding to the transition period from pediatric to adult medical care, and this increase was similar during 1979-1998. Although the age groups with the highest mortality were 35-44 years for males and 45-54 years for females, there was a tendency for longer survival because there were more deaths among those individuals 55-74 years of age compared to previous years. For all individuals, the causes of deaths were cardiac disease (31.6%), respiratory (28.1%), renal (16.4%), infectious (14.4%), neurologic (11.9%), and gastrointestinal and hepatobiliary (9.2%) in nature. Cancer was the cause of death in <1%. Conclusion: Mortality during childhood has decreased significantly. However, the transition period from pediatric to adult care is critical. Risk-reduction, monitoring, and early treatment intervention of cardiovascular disease in adults is warranted.
AB - Background: Little is known about the national outcome of children and adults with sickle cell disease (SCD) given contemporary care. Procedure: We investigated the number of deaths, standardized crude and age-adjusted mortality rates, and causes of death among individuals with SCD across the United States during 1999-2009 according to death certificates by using a publicly available website (http://wonder.cdc.gov/). Data were compared to mortality during 1979-1998. Results: When compared to 1979-1998, mortality significantly decreased by 61% in infants <1 year of age, by 67% in children aged 1-4 years, and by 22-35% in children aged 5-19 years. After 19 years of age, mortality rates increased from 0.6 in the 15-19 year group to 1.4/100,000 in the 20-24 year group, corresponding to the transition period from pediatric to adult medical care, and this increase was similar during 1979-1998. Although the age groups with the highest mortality were 35-44 years for males and 45-54 years for females, there was a tendency for longer survival because there were more deaths among those individuals 55-74 years of age compared to previous years. For all individuals, the causes of deaths were cardiac disease (31.6%), respiratory (28.1%), renal (16.4%), infectious (14.4%), neurologic (11.9%), and gastrointestinal and hepatobiliary (9.2%) in nature. Cancer was the cause of death in <1%. Conclusion: Mortality during childhood has decreased significantly. However, the transition period from pediatric to adult care is critical. Risk-reduction, monitoring, and early treatment intervention of cardiovascular disease in adults is warranted.
KW - Mortality
KW - Sickle cell disease
KW - Survival
KW - Transition
UR - http://www.scopus.com/inward/record.url?scp=84880360759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880360759&partnerID=8YFLogxK
U2 - 10.1002/pbc.24557
DO - 10.1002/pbc.24557
M3 - Article
C2 - 23637037
AN - SCOPUS:84880360759
VL - 60
SP - 1482
EP - 1486
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 9
ER -