TY - JOUR
T1 - Sibling risks in cancer
T2 - Clues to recessive or X-linked genes?
AU - Hemminki, K.
AU - Vaittinen, P.
AU - Dong, C.
AU - Easton, D.
N1 - Funding Information:
The work was supported by The Cancer Fund.
PY - 2001
Y1 - 2001
N2 - A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried out based on the nationwide Swedish Family-Cancer Database. For all 13 cancer sites examined, risks to both offspring and siblings of cases of cancer at the same site were significantly elevated. The relative risk to siblings was approximately 2 fold more than the offspring risk for cancers of the prostate, testis, kidney and bladder, suggesting that recessive or X-linked susceptibility genes may be important for these cancers. Risks to siblings of cases where a parent was also affected were increased >20 fold over population rates for colorectal, ovarian, prostate and renal cancer, and for leukaemia, consistent with the effects of rare high-risk susceptibility alleles.
AB - A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried out based on the nationwide Swedish Family-Cancer Database. For all 13 cancer sites examined, risks to both offspring and siblings of cases of cancer at the same site were significantly elevated. The relative risk to siblings was approximately 2 fold more than the offspring risk for cancers of the prostate, testis, kidney and bladder, suggesting that recessive or X-linked susceptibility genes may be important for these cancers. Risks to siblings of cases where a parent was also affected were increased >20 fold over population rates for colorectal, ovarian, prostate and renal cancer, and for leukaemia, consistent with the effects of rare high-risk susceptibility alleles.
KW - Cancer modelling
KW - Familial cancer
KW - Genetic epidemiology
KW - Heredity
KW - Liability
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U2 - 10.1054/bjoc.2000.1585
DO - 10.1054/bjoc.2000.1585
M3 - Article
C2 - 11161404
AN - SCOPUS:0035121849
VL - 84
SP - 388
EP - 391
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 3
ER -
