Should ventricular fibrillation be induced prior to the infusion of cardioplegic solution?

Tomas Salerno, M. A. Chiong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalAnnals of Thoracic Surgery
Volume35
Issue number4
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Cardioplegic Solutions
Ventricular Fibrillation
Pericardium
Constriction
Endocardium
Phosphocreatine
Cardiopulmonary Bypass
Glycogen
Aorta
Swine
Adenosine Triphosphate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Should ventricular fibrillation be induced prior to the infusion of cardioplegic solution? / Salerno, Tomas; Chiong, M. A.

In: Annals of Thoracic Surgery, Vol. 35, No. 4, 01.01.1983, p. 367-371.

Research output: Contribution to journalArticle

@article{f4a376b2503742aa8690a40ac915962b,
title = "Should ventricular fibrillation be induced prior to the infusion of cardioplegic solution?",
abstract = "The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.",
author = "Tomas Salerno and Chiong, {M. A.}",
year = "1983",
month = "1",
day = "1",
language = "English",
volume = "35",
pages = "367--371",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Should ventricular fibrillation be induced prior to the infusion of cardioplegic solution?

AU - Salerno, Tomas

AU - Chiong, M. A.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.

AB - The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.

UR - http://www.scopus.com/inward/record.url?scp=0020581173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020581173&partnerID=8YFLogxK

M3 - Article

C2 - 6838264

AN - SCOPUS:0020581173

VL - 35

SP - 367

EP - 371

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 4

ER -