Should status II patients be removed from the pediatric heart transplant waiting list? A multi-institutional study

J. K. Kirklin, D. C. Naftel, R. L. Caldwell, F. B. Pearce, H. Bartlett, P. Rusconi, C. White-Williams, B. V. Robinson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: The survival benefit of cardiac transplantation (CTx) among Status 2 (stable outpatient) adult recipients has been questioned, but few studies have addressed this issue in pediatric patients. This study examined the following hypothesis: "Status 2 pediatric recipients have a survival benefit with CTx." Methods: Between 1993 and 2003, 2,375 patients were listed for CTx at 24 institutions; 614 (26%) of these patients were Status 2. By multivariate competing outcomes hazard function analysis, death after listing and post-transplant survival were analyzed. Results: A single-phase hazard function described the risk of death after listing, with 20% actual mortality within 2 months after Status 1 listing. The "natural history" of Status 2-listed patients was estimated by the risk of death, whereas waiting and risk of deterioration to Status 1 at CTx (weighted by the probability of death at 3 months after Status 1 listing). At 4 months after CTx, survival with CTx exceeded the predicted "natural Hx" survival in all diagnostic categories out to 4 years of follow-up. Conclusions: Pediatric patients currently listed as Status 2 have a survival benefit with transplant out to at least 4 years. A pediatric allocation system restricted to Status 1 patients could only be justified if the vast majority of such patients could be transplanted within 1 to 2 months.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2006

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Fingerprint Dive into the research topics of 'Should status II patients be removed from the pediatric heart transplant waiting list? A multi-institutional study'. Together they form a unique fingerprint.

  • Cite this

    Kirklin, J. K., Naftel, D. C., Caldwell, R. L., Pearce, F. B., Bartlett, H., Rusconi, P., White-Williams, C., & Robinson, B. V. (2006). Should status II patients be removed from the pediatric heart transplant waiting list? A multi-institutional study. Journal of Heart and Lung Transplantation, 25(3), 271-275. https://doi.org/10.1016/j.healun.2005.10.003