Short-term effect of atorvastatin on carotid artery elasticity: A pilot study

Elizabeth V. Ratchford, Jose Gutierrez, Dalia Lorenzo, Mark S. McClendon, David Della-Morte, Janet T. Derosa, Mitchell S.V. Elkind, Ralph L. Sacco, Tatjana Rundek

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background and Purpose: Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods: The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 ±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results: Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of ≥10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL. Conclusions: Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.

Original languageEnglish (US)
Pages (from-to)3460-3464
Number of pages5
JournalStroke
Volume42
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • Carotid arteries
  • Carotid ultrasound
  • Elasticity
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Fingerprint Dive into the research topics of 'Short-term effect of atorvastatin on carotid artery elasticity: A pilot study'. Together they form a unique fingerprint.

  • Cite this

    Ratchford, E. V., Gutierrez, J., Lorenzo, D., McClendon, M. S., Della-Morte, D., Derosa, J. T., Elkind, M. S. V., Sacco, R. L., & Rundek, T. (2011). Short-term effect of atorvastatin on carotid artery elasticity: A pilot study. Stroke, 42(12), 3460-3464. https://doi.org/10.1161/STROKEAHA.111.625418