Short-term effect of atorvastatin on carotid artery elasticity: A pilot study

Elizabeth V. Ratchford, Jose Gutierrez, Dalia Lorenzo, Mark S. McClendon, David Della Morte, Janet T. Derosa, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Purpose: Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods: The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 ±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results: Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of ≥10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL. Conclusions: Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.

Original languageEnglish
Pages (from-to)3460-3464
Number of pages5
JournalStroke
Volume42
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

Elasticity
Carotid Arteries
Confidence Intervals
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Biomarkers
Blood Pressure
Common Carotid Artery
LDL Lipoproteins
Hispanic Americans
Atherosclerosis
Stroke
Outcome Assessment (Health Care)
Clinical Trials
Atorvastatin Calcium
Therapeutics

Keywords

  • Carotid arteries
  • Carotid ultrasound
  • Elasticity
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Ratchford, E. V., Gutierrez, J., Lorenzo, D., McClendon, M. S., Della Morte, D., Derosa, J. T., ... Rundek, T. (2011). Short-term effect of atorvastatin on carotid artery elasticity: A pilot study. Stroke, 42(12), 3460-3464. https://doi.org/10.1161/STROKEAHA.111.625418

Short-term effect of atorvastatin on carotid artery elasticity : A pilot study. / Ratchford, Elizabeth V.; Gutierrez, Jose; Lorenzo, Dalia; McClendon, Mark S.; Della Morte, David; Derosa, Janet T.; Elkind, Mitchell S V; Sacco, Ralph L; Rundek, Tatjana.

In: Stroke, Vol. 42, No. 12, 01.12.2011, p. 3460-3464.

Research output: Contribution to journalArticle

Ratchford, EV, Gutierrez, J, Lorenzo, D, McClendon, MS, Della Morte, D, Derosa, JT, Elkind, MSV, Sacco, RL & Rundek, T 2011, 'Short-term effect of atorvastatin on carotid artery elasticity: A pilot study', Stroke, vol. 42, no. 12, pp. 3460-3464. https://doi.org/10.1161/STROKEAHA.111.625418
Ratchford EV, Gutierrez J, Lorenzo D, McClendon MS, Della Morte D, Derosa JT et al. Short-term effect of atorvastatin on carotid artery elasticity: A pilot study. Stroke. 2011 Dec 1;42(12):3460-3464. https://doi.org/10.1161/STROKEAHA.111.625418
Ratchford, Elizabeth V. ; Gutierrez, Jose ; Lorenzo, Dalia ; McClendon, Mark S. ; Della Morte, David ; Derosa, Janet T. ; Elkind, Mitchell S V ; Sacco, Ralph L ; Rundek, Tatjana. / Short-term effect of atorvastatin on carotid artery elasticity : A pilot study. In: Stroke. 2011 ; Vol. 42, No. 12. pp. 3460-3464.
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abstract = "Background and Purpose: Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods: The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 ±7 years; 55{\%} men; 64{\%} Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results: Baseline mean stiffness was 0.08 (95{\%} confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of ≥10{\%} from baseline was observed in 29 (73{\%}) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL. Conclusions: Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.",
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AU - Gutierrez, Jose

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AU - Della Morte, David

AU - Derosa, Janet T.

AU - Elkind, Mitchell S V

AU - Sacco, Ralph L

AU - Rundek, Tatjana

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N2 - Background and Purpose: Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods: The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 ±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results: Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of ≥10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL. Conclusions: Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.

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