Short-term complications of intravitreal injection of triamcinolone acetonide

Daniel B. Roth, Tony Realini, William J. Feuer, Ravi Radhakrishnan, Jonathan Gloth, Mark R. Heimmel, Robert D. Fechtner, David L. Yarian, Stuart N. Green

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

PURPOSE: To describe the short-term complications associated with intravitreal triamcinolone acetonide (IVTA) injection in the treatment of posterior segment disorders. METHODS: The medical records of 784 patients (929 consecutive eyes) were retrospectively reviewed at a single institution. One or more IVTA injections for treatment of a variety of steroid-responsive posterior segment disorders (predominantly diabetic macular edema, choroidal neovascularization, and retinal venous occlusions) were administered. Adverse events occurring within 3 months of the initial injection were identified. RESULTS: The most common adverse event occurring within 3 months after the initial injection was steroid-related ocular hypertension, with intraocular pressure spikes of >21 mm Hg in 21% of eyes and >25 mm Hg in 11% of eyes. Ocular inflammation occurred in six eyes (0.6%): four eyes with sterile hypopyon and two eyes without hypopyon. Three eyes (0.3%) had corneal epithelial defects thought to be related to pretreatment with povidone-iodine solution. No eyes had culture-positive infectious endophthalmitis. Cataract progression was not assessed in this analysis. CONCLUSION: IVTA injection for the treatment of steroid-responsive disorders of the posterior segment, when administered under sterile conditions, is associated with a low incidence of serious vision-threatening adverse events within the first 3 months after injection.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalRetina
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Complications
  • Endophthalmitis
  • Injection
  • Intraocular pressure
  • Intravitreal triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology

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