Short-term complications of intravitreal injection of triamcinolone acetonide

Daniel B. Roth, Tony Realini, William J Feuer, Ravi Radhakrishnan, Jonathan Gloth, Mark R. Heimmel, Robert D. Fechtner, David L. Yarian, Stuart N. Green

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

PURPOSE: To describe the short-term complications associated with intravitreal triamcinolone acetonide (IVTA) injection in the treatment of posterior segment disorders. METHODS: The medical records of 784 patients (929 consecutive eyes) were retrospectively reviewed at a single institution. One or more IVTA injections for treatment of a variety of steroid-responsive posterior segment disorders (predominantly diabetic macular edema, choroidal neovascularization, and retinal venous occlusions) were administered. Adverse events occurring within 3 months of the initial injection were identified. RESULTS: The most common adverse event occurring within 3 months after the initial injection was steroid-related ocular hypertension, with intraocular pressure spikes of >21 mm Hg in 21% of eyes and >25 mm Hg in 11% of eyes. Ocular inflammation occurred in six eyes (0.6%): four eyes with sterile hypopyon and two eyes without hypopyon. Three eyes (0.3%) had corneal epithelial defects thought to be related to pretreatment with povidone-iodine solution. No eyes had culture-positive infectious endophthalmitis. Cataract progression was not assessed in this analysis. CONCLUSION: IVTA injection for the treatment of steroid-responsive disorders of the posterior segment, when administered under sterile conditions, is associated with a low incidence of serious vision-threatening adverse events within the first 3 months after injection.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalRetina
Volume28
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Triamcinolone Acetonide
Intravitreal Injections
Injections
Steroids
Povidone-Iodine
Ocular Hypertension
Choroidal Neovascularization
Endophthalmitis
Macular Edema
Intraocular Pressure
Cataract
Medical Records
Therapeutics
Inflammation

Keywords

  • Complications
  • Endophthalmitis
  • Injection
  • Intraocular pressure
  • Intravitreal triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Roth, D. B., Realini, T., Feuer, W. J., Radhakrishnan, R., Gloth, J., Heimmel, M. R., ... Green, S. N. (2008). Short-term complications of intravitreal injection of triamcinolone acetonide. Retina, 28(1), 66-70. https://doi.org/10.1097/IAE.0b013e3181593e38

Short-term complications of intravitreal injection of triamcinolone acetonide. / Roth, Daniel B.; Realini, Tony; Feuer, William J; Radhakrishnan, Ravi; Gloth, Jonathan; Heimmel, Mark R.; Fechtner, Robert D.; Yarian, David L.; Green, Stuart N.

In: Retina, Vol. 28, No. 1, 01.2008, p. 66-70.

Research output: Contribution to journalArticle

Roth, DB, Realini, T, Feuer, WJ, Radhakrishnan, R, Gloth, J, Heimmel, MR, Fechtner, RD, Yarian, DL & Green, SN 2008, 'Short-term complications of intravitreal injection of triamcinolone acetonide', Retina, vol. 28, no. 1, pp. 66-70. https://doi.org/10.1097/IAE.0b013e3181593e38
Roth DB, Realini T, Feuer WJ, Radhakrishnan R, Gloth J, Heimmel MR et al. Short-term complications of intravitreal injection of triamcinolone acetonide. Retina. 2008 Jan;28(1):66-70. https://doi.org/10.1097/IAE.0b013e3181593e38
Roth, Daniel B. ; Realini, Tony ; Feuer, William J ; Radhakrishnan, Ravi ; Gloth, Jonathan ; Heimmel, Mark R. ; Fechtner, Robert D. ; Yarian, David L. ; Green, Stuart N. / Short-term complications of intravitreal injection of triamcinolone acetonide. In: Retina. 2008 ; Vol. 28, No. 1. pp. 66-70.
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