Short report: Follow-up of Bahamian women with a BRCA1 or BRCA2 mutation

Steven A. Narod, Raleigh Butler, David Bobrowski, Mohammad R. Akbari, Du Vaughan Curling, John Lunn, Catherine Ho, Sara Panahi, Marcia Llacuachaqui, Talia Donenberg, Judith Hurley

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Purpose: We sought to determine to what extent the knowledge of carrying a BRCA1 or BRCA2 mutation influences the uptake of preventive surgeries in Bahamian women, including bilateral salpingo-oophorectomy and bilateral mastectomy. Patients and methods: The study population consisted of 78 female residents of the Bahamas for whom a BRCA1 or BRCA2 mutation had been detected between 2004 and 2014. The mean age of the 78 participants at the time of genetic testing was 46 years (age range 22–73 years). The mean time of follow-up was 4.4 years. Results: Of the 78 study participants, 19 women had a bilateral salpingo-oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%). Three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%). Conclusion: Preventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA1 or BRCA2 mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalMolecular Genetics and Genomic Medicine
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2018

Keywords

  • Bahamas
  • BRCA1
  • BRCA2
  • breast cancer
  • genetic testing
  • prophylactic bilateral mastectomy
  • prophylactic bilateral salpingo-oophorectomy

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

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  • Cite this

    Narod, S. A., Butler, R., Bobrowski, D., Akbari, M. R., Curling, D. V., Lunn, J., Ho, C., Panahi, S., Llacuachaqui, M., Donenberg, T., & Hurley, J. (2018). Short report: Follow-up of Bahamian women with a BRCA1 or BRCA2 mutation. Molecular Genetics and Genomic Medicine, 6(2), 301-304. https://doi.org/10.1002/mgg3.363