Abstract
Purpose: We sought to determine to what extent the knowledge of carrying a BRCA1 or BRCA2 mutation influences the uptake of preventive surgeries in Bahamian women, including bilateral salpingo-oophorectomy and bilateral mastectomy. Patients and methods: The study population consisted of 78 female residents of the Bahamas for whom a BRCA1 or BRCA2 mutation had been detected between 2004 and 2014. The mean age of the 78 participants at the time of genetic testing was 46 years (age range 22–73 years). The mean time of follow-up was 4.4 years. Results: Of the 78 study participants, 19 women had a bilateral salpingo-oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%). Three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%). Conclusion: Preventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA1 or BRCA2 mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 301-304 |
| Number of pages | 4 |
| Journal | Molecular Genetics and Genomic Medicine |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2018 |
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Keywords
- Bahamas
- BRCA1
- BRCA2
- breast cancer
- genetic testing
- prophylactic bilateral mastectomy
- prophylactic bilateral salpingo-oophorectomy
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
- Molecular Biology
Cite this
Short report : Follow-up of Bahamian women with a BRCA1 or BRCA2 mutation. / Narod, Steven A.; Butler, Raleigh; Bobrowski, David; Akbari, Mohammad R.; Curling, Du Vaughan; Lunn, John; Ho, Catherine; Panahi, Sara; Llacuachaqui, Marcia; Donenberg, Talia; Hurley, Judith.
In: Molecular Genetics and Genomic Medicine, Vol. 6, No. 2, 01.03.2018, p. 301-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short report
T2 - Follow-up of Bahamian women with a BRCA1 or BRCA2 mutation
AU - Narod, Steven A.
AU - Butler, Raleigh
AU - Bobrowski, David
AU - Akbari, Mohammad R.
AU - Curling, Du Vaughan
AU - Lunn, John
AU - Ho, Catherine
AU - Panahi, Sara
AU - Llacuachaqui, Marcia
AU - Donenberg, Talia
AU - Hurley, Judith
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: We sought to determine to what extent the knowledge of carrying a BRCA1 or BRCA2 mutation influences the uptake of preventive surgeries in Bahamian women, including bilateral salpingo-oophorectomy and bilateral mastectomy. Patients and methods: The study population consisted of 78 female residents of the Bahamas for whom a BRCA1 or BRCA2 mutation had been detected between 2004 and 2014. The mean age of the 78 participants at the time of genetic testing was 46 years (age range 22–73 years). The mean time of follow-up was 4.4 years. Results: Of the 78 study participants, 19 women had a bilateral salpingo-oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%). Three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%). Conclusion: Preventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA1 or BRCA2 mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized.
AB - Purpose: We sought to determine to what extent the knowledge of carrying a BRCA1 or BRCA2 mutation influences the uptake of preventive surgeries in Bahamian women, including bilateral salpingo-oophorectomy and bilateral mastectomy. Patients and methods: The study population consisted of 78 female residents of the Bahamas for whom a BRCA1 or BRCA2 mutation had been detected between 2004 and 2014. The mean age of the 78 participants at the time of genetic testing was 46 years (age range 22–73 years). The mean time of follow-up was 4.4 years. Results: Of the 78 study participants, 19 women had a bilateral salpingo-oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%). Three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%). Conclusion: Preventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA1 or BRCA2 mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized.
KW - Bahamas
KW - BRCA1
KW - BRCA2
KW - breast cancer
KW - genetic testing
KW - prophylactic bilateral mastectomy
KW - prophylactic bilateral salpingo-oophorectomy
UR - http://www.scopus.com/inward/record.url?scp=85045526939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045526939&partnerID=8YFLogxK
U2 - 10.1002/mgg3.363
DO - 10.1002/mgg3.363
M3 - Article
C2 - 29266833
AN - SCOPUS:85045526939
VL - 6
SP - 301
EP - 304
JO - Molecular genetics & genomic medicine
JF - Molecular genetics & genomic medicine
SN - 2324-9269
IS - 2
ER -