Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: Metabolite distributions and reliability

Dirk Wiedermann, Norbert Schuff, Gerald B. Matson, Brian J. Soher, Antao T. Du, Andrew A Maudsley, Michael W. Weiner

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Multislice proton magnetic resonance spectroscopic imaging (1H MRSI) at 25 ms echo time was used to measure concentrations of myo-inositol (mI), N-acetylaspartate (NAA), and creatine (Cr) and choline (Cho) in ten normal subjects between 22 and 84 years of age (mean age 44 ± 18 years). By co-analysis with MRI based tissue segmentation results, metabolite distributions were analyzed for each tissue type and for different brain regions. Measurement reliability was evaluated using intraclass correlation coefficients (ICC). Significant differences in metabolite distributions were found for all metabolites. mI of frontal gray matter was 84% of parietal gray matter and 87% of white matter. NAA of frontal gray matter was 86% of parietal gray matter and 85% of white matter. Cho of frontal gray matter was 125% of parietal gray matter and 59% of white matter and Cho of parietal gray matter was 47% of white matter. Cr of parietal gray matter was 113% of white matter. Reliability was relatively high (ICC from .70 to .93) for all metabolites in white matter and for NAA and Cr in gray matter, though limited (ICC less than .63) for mI and Cho in gray matter. These findings indicate that voxel gray/white matter contributions, regional variations in metabolite concentrations, and reliability limitations must be considered when interpreting 1H MR spectra of the brain.

Original languageEnglish
Pages (from-to)1073-1080
Number of pages8
JournalMagnetic Resonance Imaging
Volume19
Issue number8
DOIs
StatePublished - Oct 1 2001
Externally publishedYes

Fingerprint

proton magnetic resonance
metabolites
Metabolites
brain
Protons
Brain
echoes
Choline
Magnetic Resonance Imaging
Nuclear magnetic resonance
Creatine
Imaging techniques
Inositol
choline
Tissue
creatine
inositols
Magnetic resonance imaging
correlation coefficients
Gray Matter

Keywords

  • Magnetic resonance spectroscopy
  • Myo-Inositol
  • N-acetylaspartate
  • Quantitation
  • Reliability

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain : Metabolite distributions and reliability. / Wiedermann, Dirk; Schuff, Norbert; Matson, Gerald B.; Soher, Brian J.; Du, Antao T.; Maudsley, Andrew A; Weiner, Michael W.

In: Magnetic Resonance Imaging, Vol. 19, No. 8, 01.10.2001, p. 1073-1080.

Research output: Contribution to journalArticle

Wiedermann, Dirk ; Schuff, Norbert ; Matson, Gerald B. ; Soher, Brian J. ; Du, Antao T. ; Maudsley, Andrew A ; Weiner, Michael W. / Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain : Metabolite distributions and reliability. In: Magnetic Resonance Imaging. 2001 ; Vol. 19, No. 8. pp. 1073-1080.
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