Short communication

The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy

Tanvi S. Sharma, Denise L. Jacobson, Lynn Anderson, Mariana Gerschenson, Russell B. Van Dyke, Elizabeth J. Mcfarland, Tracie L Miller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mitochondrial abnormalities may lead to metabolic complications in HIV-infected children who have been receiving long-term antiretroviral treatment. We conducted a matched, case-control study comparing 21 HIV-infected children with insulin resistance (cases) to 21 HIV-infected children without insulin resistance (controls) to assess differences in mitochondrial DNA (mtDNA) copies/cell and oxidative phosphorylation NADH dehydrogenase (C1) and cytochrome c oxidase (C4) enzyme activities in peripheral blood mononuclear cells. MtDNA copies/cell tended to be lower in cases, and fasting serum glucose levels were inversely and significantly correlated with C1 enzyme activity, more so in cases. Larger pediatric studies should evaluate mitochondrial etiologies of insulin resistance and determine the role of antiretroviral therapies or HIV infection on mitochondrial dysfunction.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2013

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Insulin Resistance
Communication
HIV
NADH Dehydrogenase
Oxidative Phosphorylation
Electron Transport Complex IV
Enzymes
Mitochondrial DNA
HIV Infections
Case-Control Studies
Fasting
Blood Cells
Therapeutics
Pediatrics
Glucose
Serum

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Short communication : The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy. / Sharma, Tanvi S.; Jacobson, Denise L.; Anderson, Lynn; Gerschenson, Mariana; Van Dyke, Russell B.; Mcfarland, Elizabeth J.; Miller, Tracie L.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 9, 01.09.2013, p. 1211-1217.

Research output: Contribution to journalArticle

Sharma, Tanvi S. ; Jacobson, Denise L. ; Anderson, Lynn ; Gerschenson, Mariana ; Van Dyke, Russell B. ; Mcfarland, Elizabeth J. ; Miller, Tracie L. / Short communication : The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 9. pp. 1211-1217.
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