TY - JOUR
T1 - Short communication
T2 - The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy
AU - Sharma, Tanvi S.
AU - Jacobson, Denise L.
AU - Anderson, Lynn
AU - Gerschenson, Mariana
AU - Van Dyke, Russell B.
AU - Mcfarland, Elizabeth J.
AU - Miller, Tracie L.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Mitochondrial abnormalities may lead to metabolic complications in HIV-infected children who have been receiving long-term antiretroviral treatment. We conducted a matched, case-control study comparing 21 HIV-infected children with insulin resistance (cases) to 21 HIV-infected children without insulin resistance (controls) to assess differences in mitochondrial DNA (mtDNA) copies/cell and oxidative phosphorylation NADH dehydrogenase (C1) and cytochrome c oxidase (C4) enzyme activities in peripheral blood mononuclear cells. MtDNA copies/cell tended to be lower in cases, and fasting serum glucose levels were inversely and significantly correlated with C1 enzyme activity, more so in cases. Larger pediatric studies should evaluate mitochondrial etiologies of insulin resistance and determine the role of antiretroviral therapies or HIV infection on mitochondrial dysfunction.
AB - Mitochondrial abnormalities may lead to metabolic complications in HIV-infected children who have been receiving long-term antiretroviral treatment. We conducted a matched, case-control study comparing 21 HIV-infected children with insulin resistance (cases) to 21 HIV-infected children without insulin resistance (controls) to assess differences in mitochondrial DNA (mtDNA) copies/cell and oxidative phosphorylation NADH dehydrogenase (C1) and cytochrome c oxidase (C4) enzyme activities in peripheral blood mononuclear cells. MtDNA copies/cell tended to be lower in cases, and fasting serum glucose levels were inversely and significantly correlated with C1 enzyme activity, more so in cases. Larger pediatric studies should evaluate mitochondrial etiologies of insulin resistance and determine the role of antiretroviral therapies or HIV infection on mitochondrial dysfunction.
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U2 - 10.1089/aid.2012.0354
DO - 10.1089/aid.2012.0354
M3 - Article
C2 - 23742635
AN - SCOPUS:84882987526
VL - 29
SP - 1211
EP - 1217
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 9
ER -