Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV-positive, methamphetamine-using men who have sex with men

Adam Carrico, Violeta J. Rodriguez, Deborah Jones, Mahendra Kumar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: This study examined if methamphetamine use alone (METH + HIV−) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine-using, HIV-negative comparison group (METH-HIV−). Methods: Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV− and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH-HIV− men. Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p <.05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions: Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.

Original languageEnglish (US)
Article numbere2645
JournalHuman Psychopharmacology
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Methamphetamine
Adrenocorticotropic Hormone
Hydrocortisone
HIV
Insulin Resistance
Sleep

Keywords

  • adrenocorticotropic hormone
  • cortisol
  • HIV
  • insulin
  • methamphetamine
  • Syndemic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

@article{e57c17bf2efe425abde28c1e252e7169,
title = "Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV-positive, methamphetamine-using men who have sex with men",
abstract = "Objective: This study examined if methamphetamine use alone (METH + HIV−) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine-using, HIV-negative comparison group (METH-HIV−). Methods: Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV− and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH-HIV− men. Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p <.05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10{\%} higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions: Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.",
keywords = "adrenocorticotropic hormone, cortisol, HIV, insulin, methamphetamine, Syndemic",
author = "Adam Carrico and Rodriguez, {Violeta J.} and Deborah Jones and Mahendra Kumar",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/hup.2645",
language = "English (US)",
volume = "33",
journal = "Human Psychopharmacology",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Short circuit

T2 - Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV-positive, methamphetamine-using men who have sex with men

AU - Carrico, Adam

AU - Rodriguez, Violeta J.

AU - Jones, Deborah

AU - Kumar, Mahendra

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: This study examined if methamphetamine use alone (METH + HIV−) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine-using, HIV-negative comparison group (METH-HIV−). Methods: Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV− and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH-HIV− men. Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p <.05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions: Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.

AB - Objective: This study examined if methamphetamine use alone (METH + HIV−) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine-using, HIV-negative comparison group (METH-HIV−). Methods: Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV− and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH-HIV− men. Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p <.05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions: Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.

KW - adrenocorticotropic hormone

KW - cortisol

KW - HIV

KW - insulin

KW - methamphetamine

KW - Syndemic

UR - http://www.scopus.com/inward/record.url?scp=85040971165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040971165&partnerID=8YFLogxK

U2 - 10.1002/hup.2645

DO - 10.1002/hup.2645

M3 - Article

C2 - 29266420

AN - SCOPUS:85040971165

VL - 33

JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

IS - 1

M1 - e2645

ER -