Shark repellent lipophilic constituents in the defense secretion of the Moses sole (Pardachirus marmoratus)

Kazuo Tachibana, Samuel H. Gruber

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The defense secretion of Moses sole (Pardachirus marmoratus), the fish known to repel sharks, contains lipophilic ichthyotoxins in addition to pardaxin, a peptidic ichthyotoxin. Pardaxin has previously been regarded as the only factor responsible for the shark repellency of the secretion. On the basis of the shark repellent activity observed with the lipophile, it is considered to participate in the repellency of the secretion. Further separation of the toxic lipophile yielded five steroid monoglycosides, named mosesins. Their structures have been elucidated by nuclear magnetic resonance spectroscopy and corroborated by correlating them spectroscopically or chemically to cholic acid or to pavoninins, the related glycosides isolated from the secretion of the congeneric peacock sole, P. pavoninus.

Original languageEnglish (US)
Pages (from-to)839-853
Number of pages15
JournalToxicon
Volume26
Issue number9
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Toxicology

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