Abstract
The antibody response to dextran B1355 is thymus independent, and in high responder mice, over 90% of the antibodies carry the idiotype of an α-1,3 binding myeloma protein (J558). The present experiments demonstrate: (a) dextran B1355 is a B-cell mitogen both in a strain which carries the J558 idiotype on antibodies and in a low-responder strain which does not express that idiotype on antibodies to dextran; (b) anti-idiotypic antibodies to J558 recognize a dextran-specific surface receptor on 10-15% of all splenic B cells in those two strains as well as in all strains so far tested; (c) as shown by inhibition experiments, such surface receptors cross-react with J558, and (d) anti-idiotypic antibodies are mitogenic for spleen cells of both strains resulting in B-cell proliferation and maturation to polyclonal antibody secretion.
| Original language | English |
|---|---|
| Pages (from-to) | 862-870 |
| Number of pages | 9 |
| Journal | Journal of Experimental Medicine |
| Volume | 148 |
| Issue number | 4 |
| State | Published - Dec 1 1978 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen. / Coutinho, A.; Forni, L.; Blomberg, Bonnie B.
In: Journal of Experimental Medicine, Vol. 148, No. 4, 01.12.1978, p. 862-870.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen
AU - Coutinho, A.
AU - Forni, L.
AU - Blomberg, Bonnie B
PY - 1978/12/1
Y1 - 1978/12/1
N2 - The antibody response to dextran B1355 is thymus independent, and in high responder mice, over 90% of the antibodies carry the idiotype of an α-1,3 binding myeloma protein (J558). The present experiments demonstrate: (a) dextran B1355 is a B-cell mitogen both in a strain which carries the J558 idiotype on antibodies and in a low-responder strain which does not express that idiotype on antibodies to dextran; (b) anti-idiotypic antibodies to J558 recognize a dextran-specific surface receptor on 10-15% of all splenic B cells in those two strains as well as in all strains so far tested; (c) as shown by inhibition experiments, such surface receptors cross-react with J558, and (d) anti-idiotypic antibodies are mitogenic for spleen cells of both strains resulting in B-cell proliferation and maturation to polyclonal antibody secretion.
AB - The antibody response to dextran B1355 is thymus independent, and in high responder mice, over 90% of the antibodies carry the idiotype of an α-1,3 binding myeloma protein (J558). The present experiments demonstrate: (a) dextran B1355 is a B-cell mitogen both in a strain which carries the J558 idiotype on antibodies and in a low-responder strain which does not express that idiotype on antibodies to dextran; (b) anti-idiotypic antibodies to J558 recognize a dextran-specific surface receptor on 10-15% of all splenic B cells in those two strains as well as in all strains so far tested; (c) as shown by inhibition experiments, such surface receptors cross-react with J558, and (d) anti-idiotypic antibodies are mitogenic for spleen cells of both strains resulting in B-cell proliferation and maturation to polyclonal antibody secretion.
UR - http://www.scopus.com/inward/record.url?scp=0018124663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018124663&partnerID=8YFLogxK
M3 - Article
C2 - 81260
AN - SCOPUS:0018124663
VL - 148
SP - 862
EP - 870
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 4
ER -