Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen

Antonio Coutinho, Luciana Forni, Bonnie Blomberg

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The antibody response to dextran B1355 is thymus independent, and in high responder mice, over 90% of the antibodies carry the idiotype of an α-1,3 binding myeloma protein (J558). The present experiments demonstrate: (a) dextran B1355 is a B-cell mitogen both in a strain which carries the J558 idiotype on antibodies and in a low-responder strain which does not express that idiotype on antibodies to dextran; (b) anti-idiotypic antibodies to J558 recognize a dextran-specific surface receptor on 10-15% of all splenic B cells in those two strains as well as in all strains so far tested; (c) as shown by inhibition experiments, such surface receptors cross-react with J558, and (d) anti-idiotypic antibodies are mitogenic for spleen cells of both strains resulting in B-cell proliferation and maturation to polyclonal antibody secretion.

Original languageEnglish (US)
Pages (from-to)862-870
Number of pages9
JournalJournal of Experimental Medicine
Volume148
Issue number4
DOIs
StatePublished - Oct 1 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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