Shapes of finite two-dimensional lipid domains

Harden M. McConnell, Vincent T. Moy

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Distinct lipid domains with different two-dimensional density can be visualized in monomolecular films at the air-water interface by using fluorescence microscopy, when the monolayers are doped with a low concentration of fluorescent lipid probe. The shapes of these domains are determined to a large extent by a competition between line tension and long-range electrostatic dipolar repulsions. The line tension favors compact, often circular shapes, whereas the long-range electrostatic dipolar repulsions favor other shapes, such as thin stripes. A line integral technique is described for calculating the dipolar energies of these two-dimensional domains. Calculations are given for various domain shapes and shape transitions. It is shown that as domains grow in area they tend to thin in one dimension because of long-range dipolar forces. It is also shown how these long-range dipolar forces contribute to the formation of chiral domain shapes.

Original languageEnglish
Pages (from-to)4520-4525
Number of pages6
JournalJournal of Physical Chemistry
Volume92
Issue number15
StatePublished - Dec 1 1988
Externally publishedYes

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Lipids
lipids
Electrostatics
Monolayers
Fluorescence microscopy
Water
Air
electrostatics
monomolecular films
low concentrations
microscopy
fluorescence
probes
air
water
energy

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Shapes of finite two-dimensional lipid domains. / McConnell, Harden M.; Moy, Vincent T.

In: Journal of Physical Chemistry, Vol. 92, No. 15, 01.12.1988, p. 4520-4525.

Research output: Contribution to journalArticle

McConnell, HM & Moy, VT 1988, 'Shapes of finite two-dimensional lipid domains', Journal of Physical Chemistry, vol. 92, no. 15, pp. 4520-4525.
McConnell, Harden M. ; Moy, Vincent T. / Shapes of finite two-dimensional lipid domains. In: Journal of Physical Chemistry. 1988 ; Vol. 92, No. 15. pp. 4520-4525.
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