Sexual Behavior Patterns and PrEP Dosing Preferences in a Large Sample of North American Men Who Have Sex with Men

Conor Stack, Catie Oldenburg, Matthew Mimiaga, Steven A. Elsesser, Douglas Krakower, David S. Novak, James E. Egan, Ronald Stall, Steve Safren, Kenneth H. Mayer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Introduction: Pre-exposure prophylaxis (PrEP), taken as a single daily coformulated pill containing tenofovir -emtricitabine, is a promising intervention to reduce the likelihood of HIV acquisition in at-risk individuals, including men who have sex with men. Little is known about the acceptability of less than daily, intermittent PrEP regimens. Methods: We conducted an online survey of North American men who have sex with men to characterize their sexual frequency and planning behaviors and correlate these with PrEP dosing preferences. Results: Of the 3217 respondents who completed the survey, 46% reported engaging in unplanned condomless anal intercourse (CAI) at least once in previous 3 months and 8% reported engaging in CAI more than once per week. In multivariable analysis, reporting unplanned CAI was associated with lower educational level, identifying as homosexual/gay as compared with bisexual, being in a monogamous relationship, having a higher self-perceived risk of HIV acquisition, reporting higher income, engaging in CAI more than five times in the last 3 months, and not having visited a health care provider in the previous year. Frequent CAI (>1 time per week) was associated with being younger, identifying as homosexual/gay as compared with bisexual, being in a monogamous relationship, and having a higher self-perceived risk of HIV. Having only planned sex over the last 3 months was associated with a preference for event-based PrEP, whereas having frequent or unplanned CAI was associated with a preference for daily or time-driven PrEP regimens, respectively. Conclusion: Our findings suggest that preferences for different PrEP regimens are associated with the sexual frequency and planning behaviors of potential users.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • HIV prevention
  • PrEP
  • intermittent PrEP

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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