Sex variability of fine-needle aspiration reliability in the diagnosis of malignancy in thyroid nodules ≥4 cm

Punam P. Parikh, Bassan J. Allan, John I. Lew

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: The effect of sex on fine-needle aspiration (FNA) diagnosis of thyroid cancer remains unknown. This study determines the reliability of FNA when evaluating thyroid nodules ≥4 cm in women and men. Methods: Prospectively collected data of 1,068 patients who underwent FNA and thyroidectomy at a tertiary medical center were retrospectively reviewed. Data were stratified by sex and thyroid nodule size ≥4 cm. Results: The FNA false-negative rate for thyroid malignancy in women and men was 17% and 0%, respectively. FNA was less predictive of malignancy in women (odd ratio = 31.7; 95% confidence interval, 19.2 to 52.5; P <.0001) compared with men (odds ratio = 51.7; 95% confidence interval, 11.8 to 225.1; P <.0001) with thyroid nodules ≥4 cm. Conclusions: For the diagnosis of malignancy in large thyroid nodules, FNA may be less reliable in women compared with men. This study advocates using a more aggressive approach that includes surgical resection for definitive diagnosis in women with thyroid nodules ≥4 cm.

Original languageEnglish (US)
Pages (from-to)778-782
Number of pages5
JournalAmerican journal of surgery
Volume206
Issue number5
DOIs
StatePublished - Nov 1 2013

Keywords

  • Fine-needle aspiration
  • Sex
  • Thyroid nodules ≥4 cm

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Sex variability of fine-needle aspiration reliability in the diagnosis of malignancy in thyroid nodules ≥4 cm'. Together they form a unique fingerprint.

Cite this