TY - JOUR
T1 - Sex Disparities in Ischemic Stroke Care
T2 - FL-PR CReSD Study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities)
AU - Asdaghi, Negar
AU - Romano, Jose G.
AU - Wang, Kefeng
AU - Ciliberti-Vargas, Maria A.
AU - Koch, Sebastian
AU - Gardener, Hannah
AU - Dong, Chuanhui
AU - Rose, David Z.
AU - Waddy, Salina P.
AU - Robichaux, Mary
AU - Garcia, Enid J.
AU - Gonzalez-Sanchez, Juan A.
AU - Burgin, W. Scott
AU - Sacco, Ralph L.
AU - Rundek, Tatjana
N1 - Funding Information:
Sources of Funding The Florida Puerto Rico Collaboration to Reduce Stroke Disparities Study is supported by the National Institute of Health (NIH)/National Institute of Neurological Disorders (NINDs) and Stroke Prevention and Intervention Research Program (SPIRP) cooperative grant (grant number: U54NS081763). The women's supplement is awarded from the Office of Research on Women's Health (Grant Number: 3U54NS081763-01S1).
Publisher Copyright:
© 2016 American Heart Association, Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background and Purpose - Sex-specific disparities in stroke care including thrombolytic therapy and early hospital admission are reported. In a large registry of Florida and Puerto Rico hospitals participating in the Get With The Guidelines - Stroke program, we sought to determine sex-specific differences in ischemic stroke performance metrics and overall thrombolytic treatment. Methods - Around 51 317 (49% women) patients were included from 73 sites from 2010 to 2014. Multivariable logistic regression with generalized estimating equations evaluated sex-specific differences in the prespecified Get With The Guidelines - Stroke metrics for defect-free care in ischemic stroke, adjusting for age, race-ethnicity, insurance status, hospital characteristics, individual risk factors, and the presenting stroke severity. Results - As compared with men, women were older (73±15 versus 69±14 years; P<0.0001), more hypertensive (67% versus 63%, P<0.0001), and had more atrial fibrillation (19% versus 16%; P<0.0001). Defect-free care was slightly lower in women than in men (odds ratio, 0.96; 95% confidence interval, 0.93-1.00). Temporal trends in defect-free care improved substantially and similarly for men and women, with a 29% absolute improvement in women (P<0.0001) and 28% in men (P<0.0001), with P value of 0.13 for time-by-sex interaction. Women were less likely to receive thrombolysis (odds ratio, 0.92; 95% confidence interval, 0.86-0.99; P=0.02) and less likely to have a door-to-needle time <1 hour (odds ratio, 0.83; 95% confidence interval, 0.71-0.97; P=0.02) as compared with men. Conclusions - Women received comparable stroke care to men in this registry as measured by prespecified Get With The Guidelines metrics. However, women less likely received thrombolysis and had door-to-needle time <1 hour, an observation that calls for the implementation of interventions to reduce sex disparity in these measures.
AB - Background and Purpose - Sex-specific disparities in stroke care including thrombolytic therapy and early hospital admission are reported. In a large registry of Florida and Puerto Rico hospitals participating in the Get With The Guidelines - Stroke program, we sought to determine sex-specific differences in ischemic stroke performance metrics and overall thrombolytic treatment. Methods - Around 51 317 (49% women) patients were included from 73 sites from 2010 to 2014. Multivariable logistic regression with generalized estimating equations evaluated sex-specific differences in the prespecified Get With The Guidelines - Stroke metrics for defect-free care in ischemic stroke, adjusting for age, race-ethnicity, insurance status, hospital characteristics, individual risk factors, and the presenting stroke severity. Results - As compared with men, women were older (73±15 versus 69±14 years; P<0.0001), more hypertensive (67% versus 63%, P<0.0001), and had more atrial fibrillation (19% versus 16%; P<0.0001). Defect-free care was slightly lower in women than in men (odds ratio, 0.96; 95% confidence interval, 0.93-1.00). Temporal trends in defect-free care improved substantially and similarly for men and women, with a 29% absolute improvement in women (P<0.0001) and 28% in men (P<0.0001), with P value of 0.13 for time-by-sex interaction. Women were less likely to receive thrombolysis (odds ratio, 0.92; 95% confidence interval, 0.86-0.99; P=0.02) and less likely to have a door-to-needle time <1 hour (odds ratio, 0.83; 95% confidence interval, 0.71-0.97; P=0.02) as compared with men. Conclusions - Women received comparable stroke care to men in this registry as measured by prespecified Get With The Guidelines metrics. However, women less likely received thrombolysis and had door-to-needle time <1 hour, an observation that calls for the implementation of interventions to reduce sex disparity in these measures.
KW - Get With The Guidelines
KW - National Institute of Neurological Disorders and Stroke
KW - sex characteristics
KW - stroke
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UR - http://www.scopus.com/inward/citedby.url?scp=84983356846&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.116.013059
DO - 10.1161/STROKEAHA.116.013059
M3 - Article
C2 - 27553032
AN - SCOPUS:84983356846
VL - 47
SP - 2618
EP - 2626
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 10
ER -