Sex differences in stroke: Challenges and opportunities

Cheryl D. Bushnell, Seemant Chaturvedi, Kathy R. Gage, Paco S. Herson, Patricia D. Hurn, Monik C. Jiménez, Steven J. Kittner, Tracy E. Madsen, Louise D. McCullough, Mollie McDermott, Mathew J. Reeves, Tatjana Rundek

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Biologic sex influences many variables that are important to brain health in general, and to stroke or cerebral ischemia in particular, such as general health status, cerebrovascular anatomy and function, unique risk factors such as pregnancy and preeclampsia, symptomatology, and therapeutic response. A more complete understanding of the scale and depth of sexual dimorphism in the brain and the role of more general sex-based factors is crucial to reducing the burden of stroke in women and men. This focused review highlights recent findings in stroke, including sex differences in epidemiology, risk factor reduction, comparative use of stroke therapeutics in both sexes, the importance of frailty in women, and the biologic basis for sex differences in stroke. Such findings show tremendous promise for the future of personalized medicine in stroke prevention and treatment.

Original languageEnglish (US)
Pages (from-to)2179-2191
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number12
StatePublished - Dec 1 2018


  • Sex
  • sex differences
  • stroke
  • women

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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