Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura

Ravindra Mylvaganam, Yeon Ahn, Philippa G. Sprinz, Rolando O. Garcia, William J. Harrington

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Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R- T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (P < 0.0001) and numbers (P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (P < 0.0001) and women with disease in remission (P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R- lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.

Original languageEnglish
Pages (from-to)473-485
Number of pages13
JournalClinical Immunology and Immunopathology
Volume52
Issue number3
DOIs
StatePublished - Jan 1 1989

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Idiopathic Thrombocytopenic Purpura
Sex Characteristics
T-Lymphocytes
Lymphocytes
T-Lymphocyte Subsets
Mitogens
Population
Monoclonal Antibodies

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. / Mylvaganam, Ravindra; Ahn, Yeon; Sprinz, Philippa G.; Garcia, Rolando O.; Harrington, William J.

In: Clinical Immunology and Immunopathology, Vol. 52, No. 3, 01.01.1989, p. 473-485.

Research output: Contribution to journalArticle

Mylvaganam, Ravindra ; Ahn, Yeon ; Sprinz, Philippa G. ; Garcia, Rolando O. ; Harrington, William J. / Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. In: Clinical Immunology and Immunopathology. 1989 ; Vol. 52, No. 3. pp. 473-485.
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