Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R- T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (P < 0.0001) and numbers (P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (P < 0.0001) and women with disease in remission (P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R- lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 473-485 |
| Number of pages | 13 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 52 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1989 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
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Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. / Mylvaganam, Ravindra; Ahn, Yeon; Sprinz, Philippa G.; Garcia, Rolando O.; Harrington, William J.
In: Clinical Immunology and Immunopathology, Vol. 52, No. 3, 01.01.1989, p. 473-485.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura
AU - Mylvaganam, Ravindra
AU - Ahn, Yeon
AU - Sprinz, Philippa G.
AU - Garcia, Rolando O.
AU - Harrington, William J.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R- T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (P < 0.0001) and numbers (P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (P < 0.0001) and women with disease in remission (P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R- lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.
AB - Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R- T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (P < 0.0001) and numbers (P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (P < 0.0001) and women with disease in remission (P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R- lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=0024385880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024385880&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(89)90161-X
DO - 10.1016/0090-1229(89)90161-X
M3 - Article
C2 - 2527101
AN - SCOPUS:0024385880
VL - 52
SP - 473
EP - 485
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 3
ER -