Sevoflurane suppresses behavioral response in the rat formalin test: Combination with intrathecal lidocaine produced profound suppression of the response

Shuanglin Hao, Hidemichi Ogawa

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We investigated the effects of intrathecal (i.t.) lidocaine, inhalation sevoflurane, and a combination of i.t. lidocaine and sevoflurane on the formalin test in rats. Group 1 (control) received i.t. saline 10 μl. Groups 2 and 3 received i.t. lidocaine 200 μg and 400 μg, respectively. Groups 4- 6 received 1.2%, 2.4% and 3.6% sevoflurane, respectively. Interaction of drugs was analyzed using a dose addition model. Group 7 received i.t. lidocaine 200 μg and 1.2% sevoflurane. The biphasic behavioral activity of the hindpaw of rats was observed. This study showed that i.t. lidocaine or inhalation sevoflurane before formalin injection, significantly suppressed the behavioral activity of the hindpaw of rats, and that this suppression was significantly potentiated by the co-administration of i.t. lidocaine and inhalation sevoflurane.

Original languageEnglish (US)
Pages (from-to)124-126
Number of pages3
JournalNeuroscience Letters
Volume248
Issue number2
DOIs
StatePublished - May 29 1998
Externally publishedYes

Keywords

  • Formalin test
  • Lidocaine
  • Sevoflurane

ASJC Scopus subject areas

  • Neuroscience(all)

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