Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant

G. Noack, P. Berggren, T. Curstedt, G. Grossmann, P. Herin, W. Mortensson, R. Nilsson, B. Robertson

Research output: Contribution to journalArticle

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Abstract

Ten newborn infants (795-1680 g) with severe respiratory distress syndrome (RDS) were treated with the isolated phospholipid fraction of bovine or porcine surfactant, which was administered via the airways (dose 200 mg/kg), at a median age of 10.5 h. Before receiving surfactant, all the infants were on artificial ventilation (FiO2 0.6-1.0). Within 2 hours after surfactant replacement, the arterial-to-alveolar P(O2) ratio increased from 0.1 to 0.35. There was a concomitant improvement in lung aeration on the chest roentgenograms and a significant reduction in the right-to-left shunt. Four patients died of cerebral hemorrhage; two of them also had a patent ductus arteriosus. On surviving infant developed bronchopulmonary dysplasia, and another succumbed 8 months later to the sudden infant death syndrome. No antibodies against surfactant were detected in the sera of the survivors. Since our results show a significant improvement in lung function after replacement therapy, the efficacy of this new surfactant preparation should be further tested in randomized clinical trials.

Original languageEnglish
Pages (from-to)697-705
Number of pages9
JournalActa Paediatrica Scandinavica
Volume76
Issue number5
StatePublished - Dec 1 1987
Externally publishedYes

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Newborn Respiratory Distress Syndrome
Surface-Active Agents
Phospholipids
Bronchopulmonary Dysplasia
Lung
Patent Ductus Arteriosus
Sudden Infant Death
Cerebral Hemorrhage
Survivors
Swine
Thorax
Randomized Controlled Trials
Newborn Infant
Antibodies
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Noack, G., Berggren, P., Curstedt, T., Grossmann, G., Herin, P., Mortensson, W., ... Robertson, B. (1987). Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant. Acta Paediatrica Scandinavica, 76(5), 697-705.

Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant. / Noack, G.; Berggren, P.; Curstedt, T.; Grossmann, G.; Herin, P.; Mortensson, W.; Nilsson, R.; Robertson, B.

In: Acta Paediatrica Scandinavica, Vol. 76, No. 5, 01.12.1987, p. 697-705.

Research output: Contribution to journalArticle

Noack, G, Berggren, P, Curstedt, T, Grossmann, G, Herin, P, Mortensson, W, Nilsson, R & Robertson, B 1987, 'Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant', Acta Paediatrica Scandinavica, vol. 76, no. 5, pp. 697-705.
Noack G, Berggren P, Curstedt T, Grossmann G, Herin P, Mortensson W et al. Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant. Acta Paediatrica Scandinavica. 1987 Dec 1;76(5):697-705.
Noack, G. ; Berggren, P. ; Curstedt, T. ; Grossmann, G. ; Herin, P. ; Mortensson, W. ; Nilsson, R. ; Robertson, B. / Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant. In: Acta Paediatrica Scandinavica. 1987 ; Vol. 76, No. 5. pp. 697-705.
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