Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant

G. Noack, P. Berggren, T. Curstedt, G. Grossmann, P. Herin, W. Mortensson, R. Nilsson, B. Robertson

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Abstract

Ten newborn infants (795-1680 g) with severe respiratory distress syndrome (RDS) were treated with the isolated phospholipid fraction of bovine or porcine surfactant, which was administered via the airways (dose 200 mg/kg), at a median age of 10.5 h. Before receiving surfactant, all the infants were on artificial ventilation (FiO2 0.6-1.0). Within 2 hours after surfactant replacement, the arterial-to-alveolar P(O2) ratio increased from 0.1 to 0.35. There was a concomitant improvement in lung aeration on the chest roentgenograms and a significant reduction in the right-to-left shunt. Four patients died of cerebral hemorrhage; two of them also had a patent ductus arteriosus. On surviving infant developed bronchopulmonary dysplasia, and another succumbed 8 months later to the sudden infant death syndrome. No antibodies against surfactant were detected in the sera of the survivors. Since our results show a significant improvement in lung function after replacement therapy, the efficacy of this new surfactant preparation should be further tested in randomized clinical trials.

Original languageEnglish
Pages (from-to)697-705
Number of pages9
JournalActa Paediatrica Scandinavica
Volume76
Issue number5
StatePublished - Dec 1 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Noack, G., Berggren, P., Curstedt, T., Grossmann, G., Herin, P., Mortensson, W., Nilsson, R., & Robertson, B. (1987). Severe neonatal respiratory distress syndrome treated with the isolated phospholipid fraction of natural surfactant. Acta Paediatrica Scandinavica, 76(5), 697-705.