Abstract
To the Editor: Recombinant interferon beta-1b (Betaseron) was licensed in 1993 to reduce exacerbations of multiple sclerosis. Approval of the drug was greeted enthusiastically, despite a modest 30 percent reduction in relapses and side effects that include local inflammatory reactions and a flulike syndrome.1 We report the occurrence of severe necrotizing cutaneous reactions in a 38-year-old woman with an eight-year history of multiple sclerosis. She self-injected the standard dose of recombinant interferon beta-1b (9 million units) subcutaneously on alternate days. Erythematous patches appeared at the injection sites on both thighs during the third month of treatment. These areas became violaceous,.
Original language | English (US) |
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Pages (from-to) | 1584-1585 |
Number of pages | 2 |
Journal | New England Journal of Medicine |
Volume | 332 |
Issue number | 23 |
DOIs | |
State | Published - Jun 8 1995 |
ASJC Scopus subject areas
- Medicine(all)