Abstract
Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24+/Vβ11 + natural killer T (NKT) cells, but not NK cells or CD4+ or CD8+ T cells. Neither the blood nor marrow of MDS patients had detectable interferon-γ-producing NKT cells in response to the NKT ligand, α-galactosyl ceramide, although influenza-virus-specific effector T-cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.
Original language | English (US) |
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Pages (from-to) | 617-622 |
Number of pages | 6 |
Journal | British Journal of Haematology |
Volume | 122 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2003 |
Externally published | Yes |
Keywords
- CD1d
- Glycolipids
- Innate immunity
- Myelodysplastic syndromes
- Natural killer T cells
ASJC Scopus subject areas
- Hematology