Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes

Shin Ichiro Fujii, Kanako Shimizu, Virginia Klimek, Matthew D. Geller, Stephen D. Nimer, Madhav V. Dhodapkar

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24+/Vβ11 + natural killer T (NKT) cells, but not NK cells or CD4+ or CD8+ T cells. Neither the blood nor marrow of MDS patients had detectable interferon-γ-producing NKT cells in response to the NKT ligand, α-galactosyl ceramide, although influenza-virus-specific effector T-cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalBritish Journal of Haematology
Volume122
Issue number4
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • CD1d
  • Glycolipids
  • Innate immunity
  • Myelodysplastic syndromes
  • Natural killer T cells

ASJC Scopus subject areas

  • Hematology

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