Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes

Shin Ichiro Fujii; Kanako Shimizu; Virginia Klimek; Matthew D. Geller; Stephen D. Nimer; Madhav V. Dhodapkar

doi:10.1046/j.1365-2141.2003.04465.x

Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes

Shin Ichiro Fujii, Kanako Shimizu, Virginia Klimek, Matthew D. Geller, Stephen D. Nimer, Madhav V. Dhodapkar

Research output: Contribution to journal › Article

86 Scopus citations

Abstract

Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24⁺/Vβ11 ⁺ natural killer T (NKT) cells, but not NK cells or CD4⁺ or CD8⁺ T cells. Neither the blood nor marrow of MDS patients had detectable interferon-γ-producing NKT cells in response to the NKT ligand, α-galactosyl ceramide, although influenza-virus-specific effector T-cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.

Original language	English (US)
Pages (from-to)	617-622
Number of pages	6
Journal	British Journal of Haematology
Volume	122
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04465.x
State	Published - Aug 1 2003
Externally published	Yes

Keywords

CD1d
Glycolipids
Innate immunity
Myelodysplastic syndromes
Natural killer T cells

ASJC Scopus subject areas

Hematology

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Fujii, S. I., Shimizu, K., Klimek, V., Geller, M. D., Nimer, S. D., & Dhodapkar, M. V. (2003). Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes. British Journal of Haematology, 122(4), 617-622. https://doi.org/10.1046/j.1365-2141.2003.04465.x

Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes. / Fujii, Shin Ichiro; Shimizu, Kanako; Klimek, Virginia; Geller, Matthew D.; Nimer, Stephen D.; Dhodapkar, Madhav V.

In: British Journal of Haematology, Vol. 122, No. 4, 01.08.2003, p. 617-622.

Research output: Contribution to journal › Article

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