Serum vitamin A concentrations in a North American cohort of human immunodeficiency virus type 1-infected children

Jennifer S. Read, James Bethel, D. Robert Harris, William A. Meyer, James Korelitz, Lynne M. Mofenson, John Move, Savita Pahwa, Kenneth Rich, Robert P. Nugent

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background. Vitamin A deficiency is associated with increased risks of vertical transmission of HIV-1 (HIV) and of disease progression and mortality among HIV-infected adults. The objectives of the study were to describe serum vitamin A concentrations among HIV-infected children in the National Institute of Child Health and Human Development MG Clinical Trial, to examine changes in vitamin A concentrations and to investigate the relationships between vitamin A concentrations and morbidity and mortality. Methods. Blood was collected from children at baseline and at 3-month intervals throughout the study. Serum samples were stored at -70°C at a central repository until retrieved for vitamin A assay. Samples were hexane-extracted and assayed by high performance liquid chromatography. The rate of change in vitamin A concentrations, calculated by fitting a linear regression model, was expressed as micrograms/dl/year. Results. The median vitamin A concentration at baseline (n = 207 children) was 31.0 μg/dl [range, undetectable (<10 μg/dl) to 98 μg/dl]. The rate of change in vitamin A concentrations (n = 180 children) did not vary significantly by any factor other than baseline vitamin A concentration. Baseline vitamin A concentration was not associated with morbidity (incidence of infections, growth failure, CD4+ percent decline below 15%, increases in serum HIV RNA concentrations above either 105 or 106 copies/ml or acute care hospitalization). Neither baseline vitamin A concentration nor the rate of change of vitamin A concentrations was associated with mortality. Conclusions. Among these North American children with relatively normal vitamin A concentrations, vitamin A was not observed to be associated with morbidity or mortality.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalPediatric Infectious Disease Journal
Volume18
Issue number2
DOIs
StatePublished - Feb 1999
Externally publishedYes

Keywords

  • Disease progression
  • Human immunodeficiency virus
  • Mortality
  • Vitamin A

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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