Abstract
In a joint Veterans Administration-National Heart, Lung, and Blood Institute study of mild hypertension, 1,012 men and women, 21 to 50 years of age and with diastolic pressure from 85 to 105 mm Hg, were randomized into two double-blind treatment groups. Subjects in the active group received chlorthalidone or chlorthalidone plus reserpine, while the other subjects received matching placebo tablets. After one year of treatment, the chlorthalidone group had increases of 10.0±1.8 (SE) mg/dL in total cholesterol level, 9.8±5.2 mg/dL in triglyceride level, and 12.6±3.4 mg/dL in low-density lipoprotein-cholesterol level above the changes in the placebo group. There was no difference in high-density lipoprotein changes between the two groups (0.1±0.8 mg/dL). The possible net effect on risk of increasing lipid values while lowering pressure in the long-term treatment of mild hypertension with thiazides or related diuretics must be further evaluated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1691-1695 |
| Number of pages | 5 |
| Journal | JAMA - Journal of the American Medical Association |
| Volume | 244 |
| Issue number | 15 |
| DOIs | |
| State | Published - Oct 10 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Serum Lipoprotein Levels During Chlorthalidone Therapy : A Veterans Administration-National Heart, Lung, and Blood Institute Cooperative Study on Antihypertensive Therapy: Mild Hypertension. / Goldman, Anne I.; Steele, Bernard W; Schnaper, Harold W.; Perry, H. Mitchell; Fitz, Annette E.; Frohlich, Edward D.
In: JAMA - Journal of the American Medical Association, Vol. 244, No. 15, 10.10.1980, p. 1691-1695.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum Lipoprotein Levels During Chlorthalidone Therapy
T2 - A Veterans Administration-National Heart, Lung, and Blood Institute Cooperative Study on Antihypertensive Therapy: Mild Hypertension
AU - Goldman, Anne I.
AU - Steele, Bernard W
AU - Schnaper, Harold W.
AU - Perry, H. Mitchell
AU - Fitz, Annette E.
AU - Frohlich, Edward D.
PY - 1980/10/10
Y1 - 1980/10/10
N2 - In a joint Veterans Administration-National Heart, Lung, and Blood Institute study of mild hypertension, 1,012 men and women, 21 to 50 years of age and with diastolic pressure from 85 to 105 mm Hg, were randomized into two double-blind treatment groups. Subjects in the active group received chlorthalidone or chlorthalidone plus reserpine, while the other subjects received matching placebo tablets. After one year of treatment, the chlorthalidone group had increases of 10.0±1.8 (SE) mg/dL in total cholesterol level, 9.8±5.2 mg/dL in triglyceride level, and 12.6±3.4 mg/dL in low-density lipoprotein-cholesterol level above the changes in the placebo group. There was no difference in high-density lipoprotein changes between the two groups (0.1±0.8 mg/dL). The possible net effect on risk of increasing lipid values while lowering pressure in the long-term treatment of mild hypertension with thiazides or related diuretics must be further evaluated.
AB - In a joint Veterans Administration-National Heart, Lung, and Blood Institute study of mild hypertension, 1,012 men and women, 21 to 50 years of age and with diastolic pressure from 85 to 105 mm Hg, were randomized into two double-blind treatment groups. Subjects in the active group received chlorthalidone or chlorthalidone plus reserpine, while the other subjects received matching placebo tablets. After one year of treatment, the chlorthalidone group had increases of 10.0±1.8 (SE) mg/dL in total cholesterol level, 9.8±5.2 mg/dL in triglyceride level, and 12.6±3.4 mg/dL in low-density lipoprotein-cholesterol level above the changes in the placebo group. There was no difference in high-density lipoprotein changes between the two groups (0.1±0.8 mg/dL). The possible net effect on risk of increasing lipid values while lowering pressure in the long-term treatment of mild hypertension with thiazides or related diuretics must be further evaluated.
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U2 - 10.1001/jama.1980.03310150027023
DO - 10.1001/jama.1980.03310150027023
M3 - Article
AN - SCOPUS:84912783482
VL - 244
SP - 1691
EP - 1695
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 15
ER -