Serum lidocaine concentrations following subcutaneous administration

J. A. Barone, Richard S Weisman, R. A. Mangione, L. R. Goldfrank

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Serum lidocaine concentrations were determined following subcutaneous administration for local anesthesia in the management of lacerations in the emergency room setting. Thirty patients received doses of lidocaine hydrochloride 1% solution ranging from 10 to 300 mg. Venous blood samples were drawn 15, 30, 45, and 60 minutes after lidocaine administration. Serum lidocaine determinations were made using an immunoassay system and verified by gas chromatography. There was no evidence of lidocaine absorption from the subcutaneous injection sites. There were no detectable concentrations of lidocaine in any of the patient blood samples. The absorption characteristics of subcutaneously administered lidocaine appear to be altered in traumatized tissue.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalClinical Pharmacy
Volume3
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Lidocaine
Serum
Lacerations
Local Anesthesia
Subcutaneous Injections
Immunoassay
Gas Chromatography
Hospital Emergency Service

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Barone, J. A., Weisman, R. S., Mangione, R. A., & Goldfrank, L. R. (1984). Serum lidocaine concentrations following subcutaneous administration. Clinical Pharmacy, 3(3), 281-284.

Serum lidocaine concentrations following subcutaneous administration. / Barone, J. A.; Weisman, Richard S; Mangione, R. A.; Goldfrank, L. R.

In: Clinical Pharmacy, Vol. 3, No. 3, 01.01.1984, p. 281-284.

Research output: Contribution to journalArticle

Barone, JA, Weisman, RS, Mangione, RA & Goldfrank, LR 1984, 'Serum lidocaine concentrations following subcutaneous administration', Clinical Pharmacy, vol. 3, no. 3, pp. 281-284.
Barone JA, Weisman RS, Mangione RA, Goldfrank LR. Serum lidocaine concentrations following subcutaneous administration. Clinical Pharmacy. 1984 Jan 1;3(3):281-284.
Barone, J. A. ; Weisman, Richard S ; Mangione, R. A. ; Goldfrank, L. R. / Serum lidocaine concentrations following subcutaneous administration. In: Clinical Pharmacy. 1984 ; Vol. 3, No. 3. pp. 281-284.
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