Serum lidocaine concentrations following subcutaneous administration

J. A. Barone, R. Weisman, R. A. Mangione, L. R. Goldfrank

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Serum lidocaine concentrations were determined following subcutaneous administration for local anesthesia in the management of lacerations in the emergency room setting. Thirty patients received doses of lidocaine hydrochloride 1% solution ranging from 10 to 300 mg. Venous blood samples were drawn 15, 30, 45, and 60 minutes after lidocaine administration. Serum lidocaine determinations were made using an immunoassay system and verified by gas chromatography. There was no evidence of lidocaine absorption from the subcutaneous injection sites. There were no detectable concentrations of lidocaine in any of the patient blood samples. The absorption characteristics of subcutaneously administered lidocaine appear to be altered in traumatized tissue.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalClinical Pharmacy
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science


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