Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease

James M. Noble, Nikolaos Scarmeas, Romanita S. Celenti, Mitchell S V Elkind, Clinton B Wright, Nicole Schupf, Panos N. Papapanou

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD. Methods: Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followed northern Manhattan residents aged >65 years. Mean follow-up was five years (SD 2.6). In baseline sera, serum IgG levels were determined for bacteria known to be positively or negatively associated with periodontitis (Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans Y4, Treponema denticola, Campylobacter rectus, Eubacterium nodatum, and Actinomyces naeslundii genospecies-2). In all analyses, we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis. Results: Mean age was 72 years (SD 6.9) for controls, and 79 years (SD 4.6) for cases (p<0.001). Non-Hispanic Whites comprised 26%, non-Hispanic Blacks 27%, and Hispanics 48% of the sample. In a model adjusting for baseline age, sex, education, diabetes mellitus, hypertension, smoking, prior history of stroke, and apolipoprotein E genotype, high anti-A. naeslundii titer (>640 ng/ml, present in 10% of subjects) was associated with increased risk of AD (HR=2.0, 95%CI: 1.1-3.8). This association was stronger after adjusting for other significant titers (HR=3.1, 95%CI: 1.5-6.4). In this model, high anti-E. nodatum IgG (>1755 ng/ml; 19% of subjects) was associated with lower risk of AD (HR=0.5, 95%CI: 0.2-0.9). Conclusions: Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.

Original languageEnglish
Article numbere114959
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 18 2014

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Microbiota
Alzheimer disease
Alzheimer Disease
Immunoglobulin G
Eubacterium nodatum
antibodies
Antibodies
Periodontitis
Serum
Bacteroides forsythus
Campylobacter rectus
Actinomyces naeslundii
Actinobacillus actinomycetemcomitans
Treponema denticola
Porphyromonas gingivalis
Eubacterium
Aggregatibacter actinomycetemcomitans
Actinomyces
nationalities and ethnic groups
cohort studies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Noble, J. M., Scarmeas, N., Celenti, R. S., Elkind, M. S. V., Wright, C. B., Schupf, N., & Papapanou, P. N. (2014). Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease. PLoS One, 9(12), [e114959]. https://doi.org/10.1371/journal.pone.0114959

Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease. / Noble, James M.; Scarmeas, Nikolaos; Celenti, Romanita S.; Elkind, Mitchell S V; Wright, Clinton B; Schupf, Nicole; Papapanou, Panos N.

In: PLoS One, Vol. 9, No. 12, e114959, 18.12.2014.

Research output: Contribution to journalArticle

Noble, JM, Scarmeas, N, Celenti, RS, Elkind, MSV, Wright, CB, Schupf, N & Papapanou, PN 2014, 'Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease', PLoS One, vol. 9, no. 12, e114959. https://doi.org/10.1371/journal.pone.0114959
Noble JM, Scarmeas N, Celenti RS, Elkind MSV, Wright CB, Schupf N et al. Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease. PLoS One. 2014 Dec 18;9(12). e114959. https://doi.org/10.1371/journal.pone.0114959
Noble, James M. ; Scarmeas, Nikolaos ; Celenti, Romanita S. ; Elkind, Mitchell S V ; Wright, Clinton B ; Schupf, Nicole ; Papapanou, Panos N. / Serum IgG antibody levels to periodontal microbiota are associated with incident alzheimer disease. In: PLoS One. 2014 ; Vol. 9, No. 12.
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abstract = "Background: Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD. Methods: Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followed northern Manhattan residents aged >65 years. Mean follow-up was five years (SD 2.6). In baseline sera, serum IgG levels were determined for bacteria known to be positively or negatively associated with periodontitis (Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans Y4, Treponema denticola, Campylobacter rectus, Eubacterium nodatum, and Actinomyces naeslundii genospecies-2). In all analyses, we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis. Results: Mean age was 72 years (SD 6.9) for controls, and 79 years (SD 4.6) for cases (p<0.001). Non-Hispanic Whites comprised 26{\%}, non-Hispanic Blacks 27{\%}, and Hispanics 48{\%} of the sample. In a model adjusting for baseline age, sex, education, diabetes mellitus, hypertension, smoking, prior history of stroke, and apolipoprotein E genotype, high anti-A. naeslundii titer (>640 ng/ml, present in 10{\%} of subjects) was associated with increased risk of AD (HR=2.0, 95{\%}CI: 1.1-3.8). This association was stronger after adjusting for other significant titers (HR=3.1, 95{\%}CI: 1.5-6.4). In this model, high anti-E. nodatum IgG (>1755 ng/ml; 19{\%} of subjects) was associated with lower risk of AD (HR=0.5, 95{\%}CI: 0.2-0.9). Conclusions: Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.",
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AU - Wright, Clinton B

AU - Schupf, Nicole

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N2 - Background: Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD. Methods: Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followed northern Manhattan residents aged >65 years. Mean follow-up was five years (SD 2.6). In baseline sera, serum IgG levels were determined for bacteria known to be positively or negatively associated with periodontitis (Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans Y4, Treponema denticola, Campylobacter rectus, Eubacterium nodatum, and Actinomyces naeslundii genospecies-2). In all analyses, we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis. Results: Mean age was 72 years (SD 6.9) for controls, and 79 years (SD 4.6) for cases (p<0.001). Non-Hispanic Whites comprised 26%, non-Hispanic Blacks 27%, and Hispanics 48% of the sample. In a model adjusting for baseline age, sex, education, diabetes mellitus, hypertension, smoking, prior history of stroke, and apolipoprotein E genotype, high anti-A. naeslundii titer (>640 ng/ml, present in 10% of subjects) was associated with increased risk of AD (HR=2.0, 95%CI: 1.1-3.8). This association was stronger after adjusting for other significant titers (HR=3.1, 95%CI: 1.5-6.4). In this model, high anti-E. nodatum IgG (>1755 ng/ml; 19% of subjects) was associated with lower risk of AD (HR=0.5, 95%CI: 0.2-0.9). Conclusions: Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.

AB - Background: Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD. Methods: Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followed northern Manhattan residents aged >65 years. Mean follow-up was five years (SD 2.6). In baseline sera, serum IgG levels were determined for bacteria known to be positively or negatively associated with periodontitis (Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans Y4, Treponema denticola, Campylobacter rectus, Eubacterium nodatum, and Actinomyces naeslundii genospecies-2). In all analyses, we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis. Results: Mean age was 72 years (SD 6.9) for controls, and 79 years (SD 4.6) for cases (p<0.001). Non-Hispanic Whites comprised 26%, non-Hispanic Blacks 27%, and Hispanics 48% of the sample. In a model adjusting for baseline age, sex, education, diabetes mellitus, hypertension, smoking, prior history of stroke, and apolipoprotein E genotype, high anti-A. naeslundii titer (>640 ng/ml, present in 10% of subjects) was associated with increased risk of AD (HR=2.0, 95%CI: 1.1-3.8). This association was stronger after adjusting for other significant titers (HR=3.1, 95%CI: 1.5-6.4). In this model, high anti-E. nodatum IgG (>1755 ng/ml; 19% of subjects) was associated with lower risk of AD (HR=0.5, 95%CI: 0.2-0.9). Conclusions: Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.

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