Serum HSP70

A novel biomarker for early detection of pancreatic cancer

Sudhir K. Dutta, Mohit Girotra, Montish Singla, Anand Dutta, F. Otis Stephen, Padmanabhan P. Nair, Nipun Merchant

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objectives: Heat shock protein 70 (HSP70) is overexpressed in human pancreatic cancer cell lines. To determine if serum HSP70 levels are elevated in patients with pancreatic cancer and can function as a biomarker for early detection of pancreatic cancer. Methods: Study subjects were divided into 3 groups: histologically proven pancreatic cancer (PC; n=23), chronic pancreatitis (CP; n=12), and matched normal control subjects (C; n=10). Serum HSP70 levels were determined using a novel immunoelectrophoresis method developed and validated by the authors. Significance of difference between the groups was analyzed with analysis of variance (ANOVA). Receiver operating characteristic (ROC) curve analysis was performed to discriminate patients with pancreatic cancer from normal controls. Results: The mean ± SE serum HSP70 levels in the PC, CP, and C groups were 1.68 ± 0.083 ng/mL, 0.40 ± 0.057 ng/mL, and 0.04 ng/mL, respectively. Serum HSP70 levels in the PC group were significantly higher compared with either the CP or C groups (P < 0.01). The sensitivity and specificity of elevated serum HSP70 in the PC group was 74% and 90%, respectively. Conclusions: Serum HSP70 levels are significantly increased in patients with pancreatic cancer and may be useful as an additional biomarker for the detection of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalPancreas
Volume41
Issue number4
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

HSP70 Heat-Shock Proteins
Pancreatic Neoplasms
Early Detection of Cancer
Blood Proteins
Biomarkers
Immunoelectrophoresis
Chronic Pancreatitis
ROC Curve
Analysis of Variance
Sensitivity and Specificity
Cell Line

Keywords

  • biomarker
  • cancer
  • detection
  • HSP70
  • pancreas
  • serum

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Dutta, S. K., Girotra, M., Singla, M., Dutta, A., Otis Stephen, F., Nair, P. P., & Merchant, N. (2012). Serum HSP70: A novel biomarker for early detection of pancreatic cancer. Pancreas, 41(4), 530-534. https://doi.org/10.1097/MPA.0b013e3182374ace

Serum HSP70 : A novel biomarker for early detection of pancreatic cancer. / Dutta, Sudhir K.; Girotra, Mohit; Singla, Montish; Dutta, Anand; Otis Stephen, F.; Nair, Padmanabhan P.; Merchant, Nipun.

In: Pancreas, Vol. 41, No. 4, 05.2012, p. 530-534.

Research output: Contribution to journalArticle

Dutta, SK, Girotra, M, Singla, M, Dutta, A, Otis Stephen, F, Nair, PP & Merchant, N 2012, 'Serum HSP70: A novel biomarker for early detection of pancreatic cancer', Pancreas, vol. 41, no. 4, pp. 530-534. https://doi.org/10.1097/MPA.0b013e3182374ace
Dutta SK, Girotra M, Singla M, Dutta A, Otis Stephen F, Nair PP et al. Serum HSP70: A novel biomarker for early detection of pancreatic cancer. Pancreas. 2012 May;41(4):530-534. https://doi.org/10.1097/MPA.0b013e3182374ace
Dutta, Sudhir K. ; Girotra, Mohit ; Singla, Montish ; Dutta, Anand ; Otis Stephen, F. ; Nair, Padmanabhan P. ; Merchant, Nipun. / Serum HSP70 : A novel biomarker for early detection of pancreatic cancer. In: Pancreas. 2012 ; Vol. 41, No. 4. pp. 530-534.
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