Serum cystatin C levels in children with sickle cell disease

Ofelia A Alvarez, Gaston E Zilleruelo, Dale Wright, Brenda Montane, Gabriela Lopez-Mitnik

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Patients with sickle cell disease (SCD) may develop kidney dysfunction from childhood. The purpose of this study was to examine the value of serum cystatin C as a marker for glomerular filtration rate (GFR) in children with SCD, as compared to serum creatinine and creatinine clearance (CrCl). Twenty children (ages 9-21, ten males) with SCD with and without albuminuria were studied. The mean serum cystatin for the whole group was 0.89 mg/l (0.5-1.7 mg/l). Mean serum cystatin C was significantly different among the children with proteinuria (n=4), microalbuminuria (n=5), and without albuminuria (n=11) (1.25 mg/l, 0.84 mg/l, and 0.78 mg/l, respectively). The mean GFR derived from serum cystatin was significantly different among these subgroups, becoming abnormal in the proteinuric cohort (63 ml/min per 1.73 m2), in contrast to 94 for the microalbuminuric, and 103 for the normal subgroups. Serum creatinine (mean: 0.58 mg/dl, range: 0.3-1.1) did not change significantly with the level of albuminuria. Mean CrCl remained normal to increased within the subgroups, (133 ml/min per 1.73 m2 for those with proteinuria, 144 for those with microalbuminuria, and 163 for the normal subgroup). We conclude that serum cystatin C correlates with the level of albuminuria and may be a reliable method to measure renal function in SCD.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalPediatric Nephrology
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2006

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Cystatin C
Sickle Cell Anemia
Albuminuria
Serum
Creatinine
Cystatins
Glomerular Filtration Rate
Proteinuria
Kidney

Keywords

  • Children
  • Glomerular filtration rate
  • Hemoglobinopathy
  • Microalbuminuria
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Alvarez, O. A., Zilleruelo, G. E., Wright, D., Montane, B., & Lopez-Mitnik, G. (2006). Serum cystatin C levels in children with sickle cell disease. Pediatric Nephrology, 21(4), 533-537. https://doi.org/10.1007/s00467-006-0033-6

Serum cystatin C levels in children with sickle cell disease. / Alvarez, Ofelia A; Zilleruelo, Gaston E; Wright, Dale; Montane, Brenda; Lopez-Mitnik, Gabriela.

In: Pediatric Nephrology, Vol. 21, No. 4, 01.04.2006, p. 533-537.

Research output: Contribution to journalArticle

Alvarez, OA, Zilleruelo, GE, Wright, D, Montane, B & Lopez-Mitnik, G 2006, 'Serum cystatin C levels in children with sickle cell disease', Pediatric Nephrology, vol. 21, no. 4, pp. 533-537. https://doi.org/10.1007/s00467-006-0033-6
Alvarez, Ofelia A ; Zilleruelo, Gaston E ; Wright, Dale ; Montane, Brenda ; Lopez-Mitnik, Gabriela. / Serum cystatin C levels in children with sickle cell disease. In: Pediatric Nephrology. 2006 ; Vol. 21, No. 4. pp. 533-537.
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