Serum Cholesterol—Lowering Activity of Granulocyte-Macrophage Colony-Stimulating Factor

Stephen D. Nimer, Richard E. Champlin, David W. Golde

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Human granulocyte-macrophage colony stimulating factor (GM-CSF) is a glycoprotein hormone that stimulates the growth of hematopoietic progenitor cells and enhances the functional activity of mature myeloid effector cells. Granulocyte-macrophage colony-stimulating factor was administered to eight patients with severe aplastic anemia in an attempt to restore adequate hematopoiesis. Profound decreases in serum cholesterol concentrations were observed during GM-CSF therapy that were not dependent on changes in the patients' peripheral blood cell counts. Serum cholesterol levels decreased by an average of 37% during treatment, reaching levels of less than 4.40 mmol/L in all patients. Serum cholesterol concentrations returned to baseline in all patients after discontinuation of GM-CSF therapy. Treatment with GM-CSF prominently alters cholesterol homeostasis in vivo, although the mechanism of this effect is unknown. Our results suggest that GM-CSF may be potentially useful in the treatment of hypercholesterolemia and, possibly, in the prevention and treatment of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)3297-3300
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume260
Issue number22
DOIs
StatePublished - Dec 9 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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