Serum bile acids are higher in humans with prior gastric bypass: Potential contribution to improved glucose and lipid metabolism

Mary Elizabeth Patti, Sander M. Houten, Antonio C. Bianco, Raquel Bernier, P. Reed Larsen, Jens J. Holst, Michael K. Badman, Eleftheria Maratos-Flier, Edward C. Mun, Jussi Pihlajamaki, Johan Auwerx, Allison B. Goldfine

Research output: Contribution to journalArticle

333 Citations (Scopus)

Abstract

The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-protein coupled receptor TGR5 and the type 2 thyroid hormone deiodinase. Altered gastrointestinal anatomy following GB could affect enterohepatic recirculation of bile acids. We assessed whether circulating bile acid concentrations differ in patients who previously underwent GB, which might then contribute to improved metabolic homeostasis. We performed cross-sectional analysis of fasting serum bile acid composition and both fasting and post-meal metabolic variables, in three subject groups: (i) post-GB surgery (n = 9), (ii) without GB matched to preoperative BMI of the index cohort (n = 5), and (iii) without GB matched to current BMI of the index cohort (n = 10). Total serum bile acid concentrations were higher in GB (8.90 4.84 νmol/l) than in both overweight (3.59 1.95, P = 0.005, Ov) and severely obese (3.86 1.51, P = 0.045, MOb). Bile acid subfractions taurochenodeoxycholic, taurodeoxycholic, glycocholic, glycochenodeoxycholic, and glycodeoxycholic acids were all significantly higher in GB compared to Ov (P 0.05). Total bile acids were inversely correlated with 2-h post-meal glucose (r = 0.59, P 0.003) and fasting triglycerides (r = 0.40, P = 0.05), and positively correlated with adiponectin (r = 0.48, P 0.02) and peak glucagon-like peptide-1 (GLP-1) (r = 0.58, P 0.003). Total bile acids strongly correlated inversely with thyrotropic hormone (TSH) (r = 0.57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB.

Original languageEnglish
Pages (from-to)1671-1677
Number of pages7
JournalObesity
Volume17
Issue number9
DOIs
StatePublished - Sep 1 2009

Fingerprint

Gastric Bypass
Bile Acids and Salts
Lipid Metabolism
Glucose
Serum
Fasting
Meals
CCR10 Receptors
Glycodeoxycholic Acid
Glycochenodeoxycholic Acid
Homeostasis
Taurochenodeoxycholic Acid
Taurodeoxycholic Acid
Glycocholic Acid
Iodide Peroxidase
Glucagon-Like Peptide 1
Adiponectin
Thyroid Hormones
Weight Loss
Rodentia

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Patti, M. E., Houten, S. M., Bianco, A. C., Bernier, R., Larsen, P. R., Holst, J. J., ... Goldfine, A. B. (2009). Serum bile acids are higher in humans with prior gastric bypass: Potential contribution to improved glucose and lipid metabolism. Obesity, 17(9), 1671-1677. https://doi.org/10.1038/oby.2009.102

Serum bile acids are higher in humans with prior gastric bypass : Potential contribution to improved glucose and lipid metabolism. / Patti, Mary Elizabeth; Houten, Sander M.; Bianco, Antonio C.; Bernier, Raquel; Larsen, P. Reed; Holst, Jens J.; Badman, Michael K.; Maratos-Flier, Eleftheria; Mun, Edward C.; Pihlajamaki, Jussi; Auwerx, Johan; Goldfine, Allison B.

In: Obesity, Vol. 17, No. 9, 01.09.2009, p. 1671-1677.

Research output: Contribution to journalArticle

Patti, ME, Houten, SM, Bianco, AC, Bernier, R, Larsen, PR, Holst, JJ, Badman, MK, Maratos-Flier, E, Mun, EC, Pihlajamaki, J, Auwerx, J & Goldfine, AB 2009, 'Serum bile acids are higher in humans with prior gastric bypass: Potential contribution to improved glucose and lipid metabolism', Obesity, vol. 17, no. 9, pp. 1671-1677. https://doi.org/10.1038/oby.2009.102
Patti, Mary Elizabeth ; Houten, Sander M. ; Bianco, Antonio C. ; Bernier, Raquel ; Larsen, P. Reed ; Holst, Jens J. ; Badman, Michael K. ; Maratos-Flier, Eleftheria ; Mun, Edward C. ; Pihlajamaki, Jussi ; Auwerx, Johan ; Goldfine, Allison B. / Serum bile acids are higher in humans with prior gastric bypass : Potential contribution to improved glucose and lipid metabolism. In: Obesity. 2009 ; Vol. 17, No. 9. pp. 1671-1677.
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AU - Larsen, P. Reed

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