Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration

Igor F. Canisso, Barry A. Ball, Carolyn Cray, Neil M. Williams, Kirsten E. Scoggin, Gabriel M. Davolli, Edward L. Squires, Mats H. Troedsson

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Problem: Currently, placentitis, an important cause of late pregnancy loss in mares, is diagnosed by clinical signs and ultrasonography. Acute phase proteins (APP) are mainly produced and secreted by the liver in response to acute inflammatory stimuli. We hypothesized that APP are increased in mares with placentitis. Method of study: Concentrations of serum amyloid A (SAA), haptoglobin (Hp), fibrinogen (Fb), and white blood cell counts (WBC) were determined in plasma of mares with experimentally induced placentitis and gestationally age-matched control mares. Placentitis was induced via intracervical inoculation of Streptococcus equi subspecies zooepidemicus, a common isolate from clinical cases of bacterial placentitis. Concentrations of SAA and Hp were also determined in the 10 days pre-partum in normal mares. Results and conclusion: Mares with placentitis aborted within 5-25 days after inoculation. Concentrations of SAA and Hp rapidly increased subsequent to experimental induction of placentitis and remained increased until abortion. Neither Fb nor WBC appeared to be useful markers for placentitis. Parturition did not trigger increase in either SAA or Hp in normal foaling mares.

Original languageEnglish (US)
Pages (from-to)376-385
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume72
Issue number4
DOIs
StatePublished - Jan 1 2014

Keywords

  • Abortion
  • Acute phase proteins
  • Horse
  • Pregnancy loss

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration'. Together they form a unique fingerprint.

  • Cite this