Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration

Igor F. Canisso, Barry A. Ball, Carolyn Cray, Neil M. Williams, Kirsten E. Scoggin, Gabriel M. Davolli, Edward L. Squires, Mats H. Troedsson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Problem: Currently, placentitis, an important cause of late pregnancy loss in mares, is diagnosed by clinical signs and ultrasonography. Acute phase proteins (APP) are mainly produced and secreted by the liver in response to acute inflammatory stimuli. We hypothesized that APP are increased in mares with placentitis. Method of study: Concentrations of serum amyloid A (SAA), haptoglobin (Hp), fibrinogen (Fb), and white blood cell counts (WBC) were determined in plasma of mares with experimentally induced placentitis and gestationally age-matched control mares. Placentitis was induced via intracervical inoculation of Streptococcus equi subspecies zooepidemicus, a common isolate from clinical cases of bacterial placentitis. Concentrations of SAA and Hp were also determined in the 10 days pre-partum in normal mares. Results and conclusion: Mares with placentitis aborted within 5-25 days after inoculation. Concentrations of SAA and Hp rapidly increased subsequent to experimental induction of placentitis and remained increased until abortion. Neither Fb nor WBC appeared to be useful markers for placentitis. Parturition did not trigger increase in either SAA or Hp in normal foaling mares.

Original languageEnglish
Pages (from-to)376-385
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume72
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Serum Amyloid A Protein
Haptoglobins
Leukocyte Count
Fibrinogen
Acute-Phase Proteins
Streptococcus equi
Ultrasonography
Parturition
Pregnancy
Liver

Keywords

  • Abortion
  • Acute phase proteins
  • Horse
  • Pregnancy loss

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration. / Canisso, Igor F.; Ball, Barry A.; Cray, Carolyn; Williams, Neil M.; Scoggin, Kirsten E.; Davolli, Gabriel M.; Squires, Edward L.; Troedsson, Mats H.

In: American Journal of Reproductive Immunology, Vol. 72, No. 4, 01.01.2014, p. 376-385.

Research output: Contribution to journalArticle

Canisso, Igor F. ; Ball, Barry A. ; Cray, Carolyn ; Williams, Neil M. ; Scoggin, Kirsten E. ; Davolli, Gabriel M. ; Squires, Edward L. ; Troedsson, Mats H. / Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration. In: American Journal of Reproductive Immunology. 2014 ; Vol. 72, No. 4. pp. 376-385.
@article{0ff0762ca6ec47e3b2d48b3ff2886580,
title = "Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration",
abstract = "Problem: Currently, placentitis, an important cause of late pregnancy loss in mares, is diagnosed by clinical signs and ultrasonography. Acute phase proteins (APP) are mainly produced and secreted by the liver in response to acute inflammatory stimuli. We hypothesized that APP are increased in mares with placentitis. Method of study: Concentrations of serum amyloid A (SAA), haptoglobin (Hp), fibrinogen (Fb), and white blood cell counts (WBC) were determined in plasma of mares with experimentally induced placentitis and gestationally age-matched control mares. Placentitis was induced via intracervical inoculation of Streptococcus equi subspecies zooepidemicus, a common isolate from clinical cases of bacterial placentitis. Concentrations of SAA and Hp were also determined in the 10 days pre-partum in normal mares. Results and conclusion: Mares with placentitis aborted within 5-25 days after inoculation. Concentrations of SAA and Hp rapidly increased subsequent to experimental induction of placentitis and remained increased until abortion. Neither Fb nor WBC appeared to be useful markers for placentitis. Parturition did not trigger increase in either SAA or Hp in normal foaling mares.",
keywords = "Abortion, Acute phase proteins, Horse, Pregnancy loss",
author = "Canisso, {Igor F.} and Ball, {Barry A.} and Carolyn Cray and Williams, {Neil M.} and Scoggin, {Kirsten E.} and Davolli, {Gabriel M.} and Squires, {Edward L.} and Troedsson, {Mats H.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/aji.12278",
language = "English",
volume = "72",
pages = "376--385",
journal = "American Journal of Reproductive Immunology and Microbiology",
issn = "1046-7408",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration

AU - Canisso, Igor F.

AU - Ball, Barry A.

AU - Cray, Carolyn

AU - Williams, Neil M.

AU - Scoggin, Kirsten E.

AU - Davolli, Gabriel M.

AU - Squires, Edward L.

AU - Troedsson, Mats H.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Problem: Currently, placentitis, an important cause of late pregnancy loss in mares, is diagnosed by clinical signs and ultrasonography. Acute phase proteins (APP) are mainly produced and secreted by the liver in response to acute inflammatory stimuli. We hypothesized that APP are increased in mares with placentitis. Method of study: Concentrations of serum amyloid A (SAA), haptoglobin (Hp), fibrinogen (Fb), and white blood cell counts (WBC) were determined in plasma of mares with experimentally induced placentitis and gestationally age-matched control mares. Placentitis was induced via intracervical inoculation of Streptococcus equi subspecies zooepidemicus, a common isolate from clinical cases of bacterial placentitis. Concentrations of SAA and Hp were also determined in the 10 days pre-partum in normal mares. Results and conclusion: Mares with placentitis aborted within 5-25 days after inoculation. Concentrations of SAA and Hp rapidly increased subsequent to experimental induction of placentitis and remained increased until abortion. Neither Fb nor WBC appeared to be useful markers for placentitis. Parturition did not trigger increase in either SAA or Hp in normal foaling mares.

AB - Problem: Currently, placentitis, an important cause of late pregnancy loss in mares, is diagnosed by clinical signs and ultrasonography. Acute phase proteins (APP) are mainly produced and secreted by the liver in response to acute inflammatory stimuli. We hypothesized that APP are increased in mares with placentitis. Method of study: Concentrations of serum amyloid A (SAA), haptoglobin (Hp), fibrinogen (Fb), and white blood cell counts (WBC) were determined in plasma of mares with experimentally induced placentitis and gestationally age-matched control mares. Placentitis was induced via intracervical inoculation of Streptococcus equi subspecies zooepidemicus, a common isolate from clinical cases of bacterial placentitis. Concentrations of SAA and Hp were also determined in the 10 days pre-partum in normal mares. Results and conclusion: Mares with placentitis aborted within 5-25 days after inoculation. Concentrations of SAA and Hp rapidly increased subsequent to experimental induction of placentitis and remained increased until abortion. Neither Fb nor WBC appeared to be useful markers for placentitis. Parturition did not trigger increase in either SAA or Hp in normal foaling mares.

KW - Abortion

KW - Acute phase proteins

KW - Horse

KW - Pregnancy loss

UR - http://www.scopus.com/inward/record.url?scp=84908540642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908540642&partnerID=8YFLogxK

U2 - 10.1111/aji.12278

DO - 10.1111/aji.12278

M3 - Article

C2 - 24916762

AN - SCOPUS:84908540642

VL - 72

SP - 376

EP - 385

JO - American Journal of Reproductive Immunology and Microbiology

JF - American Journal of Reproductive Immunology and Microbiology

SN - 1046-7408

IS - 4

ER -