Serum alpha fetoprotein in 184 Ugandan patients with hepatocellular carcinoma. Clinical, laboratory, and histopathologic correlations

Charles Vogel, A. Primack, K. R. McIntire, P. P. Carbone, P. P. Anthony

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Qualitative serum alpha fetoprotein (AFP) determinations were done on sera from 184 Ugandan patients with hepatocellular carcinoma (HC) and the results correlated with clinical, laboratory, and histopathologic features of the disease. 121 (66%) were AFP positive. Young patients and those with concomitant hepatitis B antigenemia (HBAg) were AFP positive significantly more frequently than older and HBAg negative patients. There were no differences in AFP frequency between patients with or without antibody to HBAg. There was also a tendency for men and patients with poorly differentiated tumors to be positive more frequently than women or patients with well differentiated tumors. No correlations with AFP elevation were found for duration of symptoms prior to diagnosis, disease stage, patient survival, standard tests of liver function, elevations of serum proline hydroxylase or serum chorionic gonadotropin, or the presence of concomitant cirrhosis. Sensitive, standardized, quantitative AFP tests should be used in future correlative studies with special emphasis placed on patient age and HBAg.

Original languageEnglish
Pages (from-to)959-964
Number of pages6
JournalCancer
Volume33
Issue number4
DOIs
StatePublished - Dec 1 1974
Externally publishedYes

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alpha-Fetoproteins
Hepatocellular Carcinoma
Serum
Hepatitis B
Prolyl Hydroxylases
Hepatitis B Antibodies
Liver Function Tests
Chorionic Gonadotropin
Neoplasms
Fibrosis
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Serum alpha fetoprotein in 184 Ugandan patients with hepatocellular carcinoma. Clinical, laboratory, and histopathologic correlations. / Vogel, Charles; Primack, A.; McIntire, K. R.; Carbone, P. P.; Anthony, P. P.

In: Cancer, Vol. 33, No. 4, 01.12.1974, p. 959-964.

Research output: Contribution to journalArticle

Vogel, Charles ; Primack, A. ; McIntire, K. R. ; Carbone, P. P. ; Anthony, P. P. / Serum alpha fetoprotein in 184 Ugandan patients with hepatocellular carcinoma. Clinical, laboratory, and histopathologic correlations. In: Cancer. 1974 ; Vol. 33, No. 4. pp. 959-964.
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