Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish

Erin D. Michos, Elizabeth A. Streeten, Kathleen A. Ryan, Evadnie Rampersaud, Patricia A. Peyser, Lawrence F. Bielak, Alan R. Shuldiner, Braxton D. Mitchell, Wendy Post

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The relationship between vitamin D metabolites and subclinical vascular disease is controversial. Because low serum levels of 25-hydroxyvitamin D (25(OH)D) have been associated with many cardiovascular disease (CVD) risk factors, we hypothesized that serum 25(OH)D levels would be inversely associated with inflammation as measured by C-reactive protein (CRP) and with subclinical vascular disease as measured by carotid intimal medial thickness (cIMT) and coronary artery calcification (CAC). We measured 25(OH)D levels in 650 Amish participants. CAC was measured by computed tomography and cIMT by ultrasound. The associations of 25(OH)D levels with natural log(CAC + 1), cIMT, and natural log(CRP) levels were estimated after adjustment for age, sex, family structure, and season of examination. Additional analyses were carried out adjusting for body mass index (BMI) and other CVD risk factors. 25(OH)D deficiency (<20 ng/ml) and insufficiency (21-30 ng/ml) were common among the Amish (38.2% and 47.7%, respectively). 25(OH)D levels were associated with season, age, BMI, and parathyroid hormone levels. In neither the minimally or fully adjusted analyses were significant correlations observed between 25(OH)D levels and CAC, cIMT, or CRP (R 2 < 0.01 for all). Contrary to our hypothesis, this study failed to detect a cross-sectional association between serum 25(OH)D levels and CAC, cIMT, or CRP. Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalCalcified Tissue International
Volume84
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

Amish
Tunica Intima
Vascular Diseases
C-Reactive Protein
Coronary Vessels
Serum
Cardiovascular Diseases
Body Mass Index
Parathyroid Hormone
Vitamin D
Tomography
25-hydroxyvitamin D
Inflammation

Keywords

  • Coronary artery calcification
  • Inflammation
  • Steroid hormones
  • Vascular disease
  • Vitamin D

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish. / Michos, Erin D.; Streeten, Elizabeth A.; Ryan, Kathleen A.; Rampersaud, Evadnie; Peyser, Patricia A.; Bielak, Lawrence F.; Shuldiner, Alan R.; Mitchell, Braxton D.; Post, Wendy.

In: Calcified Tissue International, Vol. 84, No. 3, 01.03.2009, p. 195-202.

Research output: Contribution to journalArticle

Michos, ED, Streeten, EA, Ryan, KA, Rampersaud, E, Peyser, PA, Bielak, LF, Shuldiner, AR, Mitchell, BD & Post, W 2009, 'Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish', Calcified Tissue International, vol. 84, no. 3, pp. 195-202. https://doi.org/10.1007/s00223-008-9209-3
Michos, Erin D. ; Streeten, Elizabeth A. ; Ryan, Kathleen A. ; Rampersaud, Evadnie ; Peyser, Patricia A. ; Bielak, Lawrence F. ; Shuldiner, Alan R. ; Mitchell, Braxton D. ; Post, Wendy. / Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish. In: Calcified Tissue International. 2009 ; Vol. 84, No. 3. pp. 195-202.
@article{45155ca7967f47b8b85a3b2a70125a39,
title = "Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish",
abstract = "The relationship between vitamin D metabolites and subclinical vascular disease is controversial. Because low serum levels of 25-hydroxyvitamin D (25(OH)D) have been associated with many cardiovascular disease (CVD) risk factors, we hypothesized that serum 25(OH)D levels would be inversely associated with inflammation as measured by C-reactive protein (CRP) and with subclinical vascular disease as measured by carotid intimal medial thickness (cIMT) and coronary artery calcification (CAC). We measured 25(OH)D levels in 650 Amish participants. CAC was measured by computed tomography and cIMT by ultrasound. The associations of 25(OH)D levels with natural log(CAC + 1), cIMT, and natural log(CRP) levels were estimated after adjustment for age, sex, family structure, and season of examination. Additional analyses were carried out adjusting for body mass index (BMI) and other CVD risk factors. 25(OH)D deficiency (<20 ng/ml) and insufficiency (21-30 ng/ml) were common among the Amish (38.2{\%} and 47.7{\%}, respectively). 25(OH)D levels were associated with season, age, BMI, and parathyroid hormone levels. In neither the minimally or fully adjusted analyses were significant correlations observed between 25(OH)D levels and CAC, cIMT, or CRP (R 2 < 0.01 for all). Contrary to our hypothesis, this study failed to detect a cross-sectional association between serum 25(OH)D levels and CAC, cIMT, or CRP. Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity.",
keywords = "Coronary artery calcification, Inflammation, Steroid hormones, Vascular disease, Vitamin D",
author = "Michos, {Erin D.} and Streeten, {Elizabeth A.} and Ryan, {Kathleen A.} and Evadnie Rampersaud and Peyser, {Patricia A.} and Bielak, {Lawrence F.} and Shuldiner, {Alan R.} and Mitchell, {Braxton D.} and Wendy Post",
year = "2009",
month = "3",
day = "1",
doi = "10.1007/s00223-008-9209-3",
language = "English",
volume = "84",
pages = "195--202",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Serum 25-hydroxyvitamin D levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish

AU - Michos, Erin D.

AU - Streeten, Elizabeth A.

AU - Ryan, Kathleen A.

AU - Rampersaud, Evadnie

AU - Peyser, Patricia A.

AU - Bielak, Lawrence F.

AU - Shuldiner, Alan R.

AU - Mitchell, Braxton D.

AU - Post, Wendy

PY - 2009/3/1

Y1 - 2009/3/1

N2 - The relationship between vitamin D metabolites and subclinical vascular disease is controversial. Because low serum levels of 25-hydroxyvitamin D (25(OH)D) have been associated with many cardiovascular disease (CVD) risk factors, we hypothesized that serum 25(OH)D levels would be inversely associated with inflammation as measured by C-reactive protein (CRP) and with subclinical vascular disease as measured by carotid intimal medial thickness (cIMT) and coronary artery calcification (CAC). We measured 25(OH)D levels in 650 Amish participants. CAC was measured by computed tomography and cIMT by ultrasound. The associations of 25(OH)D levels with natural log(CAC + 1), cIMT, and natural log(CRP) levels were estimated after adjustment for age, sex, family structure, and season of examination. Additional analyses were carried out adjusting for body mass index (BMI) and other CVD risk factors. 25(OH)D deficiency (<20 ng/ml) and insufficiency (21-30 ng/ml) were common among the Amish (38.2% and 47.7%, respectively). 25(OH)D levels were associated with season, age, BMI, and parathyroid hormone levels. In neither the minimally or fully adjusted analyses were significant correlations observed between 25(OH)D levels and CAC, cIMT, or CRP (R 2 < 0.01 for all). Contrary to our hypothesis, this study failed to detect a cross-sectional association between serum 25(OH)D levels and CAC, cIMT, or CRP. Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity.

AB - The relationship between vitamin D metabolites and subclinical vascular disease is controversial. Because low serum levels of 25-hydroxyvitamin D (25(OH)D) have been associated with many cardiovascular disease (CVD) risk factors, we hypothesized that serum 25(OH)D levels would be inversely associated with inflammation as measured by C-reactive protein (CRP) and with subclinical vascular disease as measured by carotid intimal medial thickness (cIMT) and coronary artery calcification (CAC). We measured 25(OH)D levels in 650 Amish participants. CAC was measured by computed tomography and cIMT by ultrasound. The associations of 25(OH)D levels with natural log(CAC + 1), cIMT, and natural log(CRP) levels were estimated after adjustment for age, sex, family structure, and season of examination. Additional analyses were carried out adjusting for body mass index (BMI) and other CVD risk factors. 25(OH)D deficiency (<20 ng/ml) and insufficiency (21-30 ng/ml) were common among the Amish (38.2% and 47.7%, respectively). 25(OH)D levels were associated with season, age, BMI, and parathyroid hormone levels. In neither the minimally or fully adjusted analyses were significant correlations observed between 25(OH)D levels and CAC, cIMT, or CRP (R 2 < 0.01 for all). Contrary to our hypothesis, this study failed to detect a cross-sectional association between serum 25(OH)D levels and CAC, cIMT, or CRP. Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity.

KW - Coronary artery calcification

KW - Inflammation

KW - Steroid hormones

KW - Vascular disease

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=62249223963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62249223963&partnerID=8YFLogxK

U2 - 10.1007/s00223-008-9209-3

DO - 10.1007/s00223-008-9209-3

M3 - Article

C2 - 19148561

AN - SCOPUS:62249223963

VL - 84

SP - 195

EP - 202

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 3

ER -