Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma

Casandra A. Liggins, Ly T. Ma, Matthew P. Schlumbrecht

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Sertoli-Leydig cell tumors are rare sex-cord stromal tumors of the ovary that can present with a variety of histological elements, which may complicate diagnosis and treatment. Case: A 40-year-old female presenting with pelvic pain is found to have a large complex right adnexal mass and elevated alpha-fetoprotein. The mass was diagnosed as a Sertoli-Leydig cell tumor with heterologous elements including carcinoid and hepatoid components. She was treated with surgical resection followed by adjuvant chemotherapy and remains clear of disease. Conclusion: Prognostic indicators for Sertoli-Leydig cell tumors include degree and type of heterologous element differentiation. Thorough characterization of such elements is crucial for adequate diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalGynecologic Oncology Reports
StatePublished - Jan 1 2016
Externally publishedYes


  • Alphafetoprotein
  • Carcinoid
  • Endometrioid
  • Hepatoid
  • Sertoli-Leydig
  • Sex-cord

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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