Serotonin uptake and its kinetics in platelets of women with Alzheimer's Disease

Adarsh Kumar, Mahendra Kumar, Steven Sevush, Julio Ruiz, Carl Eisdorfer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The uptake of serotonin (14C-5-hydroxytryptamine, 5HT) in platelets and its kinetic characteristics were investigated in a group of women (n=20) with probable Alzheimer's Disease (mean age = 76.0, years, SD = 8.27, range = 63-88) and in healthy normal women (n = 18, mean age = 72.6 years, SD = 7.24, range = 61-84). Both the apparent affinity of binding of 5HT to the platelet membrane (Km) and the maximum velocity (Vmax) of the rate of transport of 14C-5HT into platelets were significantly higher in the Alzheimer's Disease group than in the normal comparison group. Initial velocity of 14C-5HT uptake nor passive diffusion (nonspecific uptake of 14C-5HT at 4 °C) differed significantly in the two groups. Our findings suggest abnormalities in the kinetic mechanisms involved in the uptake of 14C-5HT by platelets in women with Alzheimer's Disease.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalPsychiatry Research
Volume59
Issue number1-2
DOIs
StatePublished - Nov 29 1995

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Serotonin
Alzheimer Disease
Blood Platelets
Membranes

Keywords

  • 5-Hydroxytryptamine
  • Dementia
  • Kinetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Serotonin uptake and its kinetics in platelets of women with Alzheimer's Disease. / Kumar, Adarsh; Kumar, Mahendra; Sevush, Steven; Ruiz, Julio; Eisdorfer, Carl.

In: Psychiatry Research, Vol. 59, No. 1-2, 29.11.1995, p. 145-150.

Research output: Contribution to journalArticle

Kumar, Adarsh ; Kumar, Mahendra ; Sevush, Steven ; Ruiz, Julio ; Eisdorfer, Carl. / Serotonin uptake and its kinetics in platelets of women with Alzheimer's Disease. In: Psychiatry Research. 1995 ; Vol. 59, No. 1-2. pp. 145-150.
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