Serotonin uptake and its kinetics in platelets of women with Alzheimer's Disease

Adarsh M. Kumar, Mahendra Kumar, Steven Sevush, Julio Ruiz, Carl Eisdorfer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The uptake of serotonin (14C-5-hydroxytryptamine, 5HT) in platelets and its kinetic characteristics were investigated in a group of women (n=20) with probable Alzheimer's Disease (mean age = 76.0, years, SD = 8.27, range = 63-88) and in healthy normal women (n = 18, mean age = 72.6 years, SD = 7.24, range = 61-84). Both the apparent affinity of binding of 5HT to the platelet membrane (Km) and the maximum velocity (Vmax) of the rate of transport of 14C-5HT into platelets were significantly higher in the Alzheimer's Disease group than in the normal comparison group. Initial velocity of 14C-5HT uptake nor passive diffusion (nonspecific uptake of 14C-5HT at 4 °C) differed significantly in the two groups. Our findings suggest abnormalities in the kinetic mechanisms involved in the uptake of 14C-5HT by platelets in women with Alzheimer's Disease.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalPsychiatry Research
Volume59
Issue number1-2
DOIs
StatePublished - Nov 29 1995

Keywords

  • 5-Hydroxytryptamine
  • Dementia
  • Kinetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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