Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS

Jun He, Ganapati Bhat, Chipepo Kankasa, Chifumbe Chintu, Charles D Mitchell, Wenjing Duan, Charles Wood

Research output: Contribution to journalArticle

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Abstract

The seroprevalence of human herpesvirus 8 (HHV-8) among a group of Zambian women of reproductive age and among mother-child pairs in which either one of them has Kaposi's sarcoma (KS) was determined. A cross- sectional group of 378 pregnant women was randomly recruited into the study, and 183 (48.4%) had HHV-8 antibodies. Among the human immunodeficiency virus (HIV)-1-infected women, 51.1% were HHV-8-seropositive, whereas of HIV-1- negative women, 47.3% were HHV-8-seropositive. In addition, 21 women index patients with KS and 5 young children index patients with KS were studied. All children with KS had mothers who were HHV-8-seropositive, while not all children whose mothers had KS were infected with HHV-8. Our study suggests that there is a high HHV-8 seroprevalence among Zambian women, and the rate is almost the same in HIV-1-positive and -negative women. This high seroprevalence may be a contributing factor toward the increased frequency of KS in this population.

Original languageEnglish
Pages (from-to)1787-1790
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - Dec 18 1998
Externally publishedYes

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Human Herpesvirus 8
Kaposi's Sarcoma
Seroepidemiologic Studies
Mothers
HIV-1
Pregnant Women
Antibodies
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS. / He, Jun; Bhat, Ganapati; Kankasa, Chipepo; Chintu, Chifumbe; Mitchell, Charles D; Duan, Wenjing; Wood, Charles.

In: Journal of Infectious Diseases, Vol. 178, No. 6, 18.12.1998, p. 1787-1790.

Research output: Contribution to journalArticle

He, Jun ; Bhat, Ganapati ; Kankasa, Chipepo ; Chintu, Chifumbe ; Mitchell, Charles D ; Duan, Wenjing ; Wood, Charles. / Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 6. pp. 1787-1790.
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