Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980

P. N. Fultz, W. M. Switzer, C. A. Schable, Ronald Charles Desrosiers, D. P. Silva, J. B. McCormick

Research output: Contribution to journalArticle

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Abstract

To determine the past prevalence of HIv-1 and HIV-2 in West Africa, we tested 440 serum samples collected in 1980 from people living in rural areas of Guinea Bissau. The sera were screened for antibodies by enzyme immunoassay (EIA) using purified simian immunodeficiency virus (SIV) isolated from rhesus macaque monkeys (SIV(mac)) and then confirmed by immunoblot and immunofluorescence assays for antibodies to SIV, HIV-2, and HIV-1. Five of the serum samples were repeatedly reactive by all assays to both SIV and HIV-2. None were positive for antibodies to HIV-1 by immunofluorescence, immunoblot or radio-immunoprecipitation (RIP) assays, with the exception of one HIV-2-seropositive sample which reacted with HIV-1 glycoproteins by RIPA. Thus, in 1980, at least 1.4% (six out of 440) of a random sample of people in rural Guinea Bissau had been exposed to a virus highly related to HIV-2 and SIV. One of the subjects may have been dually infected with HIV-1 and HIV-2.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalAIDS
Volume2
Issue number2
StatePublished - 1988
Externally publishedYes

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Guinea-Bissau
HIV-2
Seroepidemiologic Studies
Simian Immunodeficiency Virus
HIV-1
Macaca mulatta
Fluorescent Antibody Technique
Antibodies
Serum
Western Africa
Radio
Immunoenzyme Techniques
Immunoprecipitation
Glycoproteins
Viruses

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Fultz, P. N., Switzer, W. M., Schable, C. A., Desrosiers, R. C., Silva, D. P., & McCormick, J. B. (1988). Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980. AIDS, 2(2), 129-132.

Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980. / Fultz, P. N.; Switzer, W. M.; Schable, C. A.; Desrosiers, Ronald Charles; Silva, D. P.; McCormick, J. B.

In: AIDS, Vol. 2, No. 2, 1988, p. 129-132.

Research output: Contribution to journalArticle

Fultz, PN, Switzer, WM, Schable, CA, Desrosiers, RC, Silva, DP & McCormick, JB 1988, 'Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980', AIDS, vol. 2, no. 2, pp. 129-132.
Fultz PN, Switzer WM, Schable CA, Desrosiers RC, Silva DP, McCormick JB. Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980. AIDS. 1988;2(2):129-132.
Fultz, P. N. ; Switzer, W. M. ; Schable, C. A. ; Desrosiers, Ronald Charles ; Silva, D. P. ; McCormick, J. B. / Seroprevalence of HIV-1 and HIV-2 in Guinea Bissau in 1980. In: AIDS. 1988 ; Vol. 2, No. 2. pp. 129-132.
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