Serologie identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III

P. J. Kanki, M. F. McLane, N. W. King, N. L. Letvin, R. D. Hunt, P. Sehgal, M. D. Daniel, R. C. Desrosiers, M. Essex

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Abstract

Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologie characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160,120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-Ill-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS.

Original languageEnglish (US)
Pages (from-to)1199-1201
Number of pages3
JournalScience
Volume228
Issue number4704
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Kanki, P. J., McLane, M. F., King, N. W., Letvin, N. L., Hunt, R. D., Sehgal, P., Daniel, M. D., Desrosiers, R. C., & Essex, M. (1985). Serologie identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III. Science, 228(4704), 1199-1201. https://doi.org/10.1126/science.3873705