Serological and structural comparison of HIV, SIVmac, SIVagm and SIVsm, four primate lentiviruses

J. Schneider, E. Jurkiewicz, M. Hayami, Ronald Charles Desrosiers, P. Marx, G. Hunsmann

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have studied the serological and structural relatedness of the human immunodeficiency virus (HIV) and three related simian immunodeficiency viruses (SIV) from rhesus monkey (mac, Macaca mulatta), African green monkey (agm, Cercopithecus aethiops) and sooty mangabey (sm, Cercocebus atys). All sera from three infected monkey species reacted with the major envelope glycoprotein gp130 of all monkey viruses, but not with the analogous gp120 of HIV. HIV-specific human antisera cross-reacted weakly with gp130 from SIVagm and SIVsm. The glycoproteins of SIVagm and SIVsm monkeys, unlike those of HIV and SIVmac, were preserved on the viral envelope during pelleting of the virus, suggesting structural similarities between the envelopes of respective viruses. Bidirectional cross-reactions were observed between core polypeptides of the four viruses examined, with the exception that, in sera of SIVagm-infected green monkeys, antibodies to viral core polypeptides were not detected. Peptide maps of core polypeptides p24 and pl8 differed among all isolates. However, with respect to p24 and pl8, HIV was more similar to SIVagm, and SIVmac to SIVsm. Since all three monkey isolates appeared to be more homogeneous in their gp130 envelope polypeptide, SIVagm may have originated by recombination of HIV and SIV ancestors.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalAnnales de l'Institut Pasteur Virology
Volume138
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Primate Lentiviruses
HIV
Cercopithecus aethiops
Haplorhini
Cercocebus atys
Peptides
Viruses
Simian Immunodeficiency Virus
Macaca mulatta
Glycoproteins
Viral Antibodies
Cross Reactions
Serum
Genetic Recombination
Immune Sera

Keywords

  • Comparaison
  • HIV, SIVmac, SIVagm, SIVsm

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Serological and structural comparison of HIV, SIVmac, SIVagm and SIVsm, four primate lentiviruses. / Schneider, J.; Jurkiewicz, E.; Hayami, M.; Desrosiers, Ronald Charles; Marx, P.; Hunsmann, G.

In: Annales de l'Institut Pasteur Virology, Vol. 138, No. 1, 01.01.1987, p. 93-99.

Research output: Contribution to journalArticle

Schneider, J. ; Jurkiewicz, E. ; Hayami, M. ; Desrosiers, Ronald Charles ; Marx, P. ; Hunsmann, G. / Serological and structural comparison of HIV, SIVmac, SIVagm and SIVsm, four primate lentiviruses. In: Annales de l'Institut Pasteur Virology. 1987 ; Vol. 138, No. 1. pp. 93-99.
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