Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group

D. Meytes, M. Elgat, B. Schochat, Y. Sidi, M. Shaklai, Y. Kilim, Y. Danon, G. Nadel, H. Lee, M. Cerney, P. Swanson, E. Chin, Joseph D Rosenblatt

Research output: Contribution to journalArticle

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Abstract

To define the extent of human T-cell leukaemia virus (HTLV-I) infection among a group of Jewish immigrants to Israel with an increased frequency of adult T-cell leukaemia, various serological and molecular screening methods, including enzyme-linked immunosorbent assay (ELISA) for anti-HTLV-I, ELISA for antibody to recombinant HTLV-I p40tax protein, and molecular detection of infection by polymerase chain reaction (PCR) amplification of HTLV-I proviral DNA from peripheral blood mononuclear cell DNA, were used. By HTLV-I ELISA the overall rate of infection was 12% (24 of 208) among immigrants from Khurusan, northeastern Iran; no HTLV-I carriers were detected among 111 unselected Jewish immigrants from other parts of Iran. There was unexplained clustering of HTLV-I infection within a cohort of 32 elderly women of similar geographic origin in a home for old people-14 were seropositive by ELISA and 19 of 29 were positive by PCR. The findings in this newly identified high-risk population suggest that in addition to ELISA, other screening techniques may be required to detect all carriers in high-risk populations.

Original languageEnglish
Pages (from-to)1533-1535
Number of pages3
JournalThe Lancet
Volume336
Issue number8730-8731
DOIs
StatePublished - Dec 22 1990
Externally publishedYes

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Deltaretrovirus
Virus Diseases
Enzyme-Linked Immunosorbent Assay
Iran
Adult T Cell Leukemia Lymphoma
Polymerase Chain Reaction
DNA
Israel
Infection
Surveys and Questionnaires
Population
Cluster Analysis
Blood Cells
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group. / Meytes, D.; Elgat, M.; Schochat, B.; Sidi, Y.; Shaklai, M.; Kilim, Y.; Danon, Y.; Nadel, G.; Lee, H.; Cerney, M.; Swanson, P.; Chin, E.; Rosenblatt, Joseph D.

In: The Lancet, Vol. 336, No. 8730-8731, 22.12.1990, p. 1533-1535.

Research output: Contribution to journalArticle

Meytes, D, Elgat, M, Schochat, B, Sidi, Y, Shaklai, M, Kilim, Y, Danon, Y, Nadel, G, Lee, H, Cerney, M, Swanson, P, Chin, E & Rosenblatt, JD 1990, 'Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group', The Lancet, vol. 336, no. 8730-8731, pp. 1533-1535. https://doi.org/10.1016/0140-6736(90)93308-C
Meytes D, Elgat M, Schochat B, Sidi Y, Shaklai M, Kilim Y et al. Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group. The Lancet. 1990 Dec 22;336(8730-8731):1533-1535. https://doi.org/10.1016/0140-6736(90)93308-C
Meytes, D. ; Elgat, M. ; Schochat, B. ; Sidi, Y. ; Shaklai, M. ; Kilim, Y. ; Danon, Y. ; Nadel, G. ; Lee, H. ; Cerney, M. ; Swanson, P. ; Chin, E. ; Rosenblatt, Joseph D. / Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group. In: The Lancet. 1990 ; Vol. 336, No. 8730-8731. pp. 1533-1535.
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