Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions - Modular solid phase synthesis of substituted octahydrobenzazepinones

Stephan C. Schürer, Siegfried Blechert

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Reaction sequences involving yne-ene cross metathesis and Diels-Alder cycloaddition reactions in solution and on solid support provide rapid access to cyclic cores incorporating variable side chains. A combinatorial approach to substituted octahydrobenzo[c]azepin-3-ones has been developed applying this chemistry in connection with a cyclization/cleavage strategy that gives rise to products of high purity.

Original languageEnglish (US)
Pages (from-to)1879-1882
Number of pages4
JournalSynlett
Issue number12
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • 1,3-dienes
  • Combinatorial chemistry
  • Cyclization/cleavage
  • Diels-Alder reactions
  • Yne-ene metathesis

ASJC Scopus subject areas

  • Organic Chemistry

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