Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions - Modular solid phase synthesis of substituted octahydrobenzazepinones

Stephan C Schuerer, Siegfried Blechert

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Reaction sequences involving yne-ene cross metathesis and Diels-Alder cycloaddition reactions in solution and on solid support provide rapid access to cyclic cores incorporating variable side chains. A combinatorial approach to substituted octahydrobenzo[c]azepin-3-ones has been developed applying this chemistry in connection with a cyclization/cleavage strategy that gives rise to products of high purity.

Original languageEnglish
Pages (from-to)1879-1882
Number of pages4
JournalSynlett
Issue number12
StatePublished - Jan 1 1999
Externally publishedYes

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Cycloaddition
Cyclization

Keywords

  • 1,3-dienes
  • Combinatorial chemistry
  • Cyclization/cleavage
  • Diels-Alder reactions
  • Yne-ene metathesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions - Modular solid phase synthesis of substituted octahydrobenzazepinones. / Schuerer, Stephan C; Blechert, Siegfried.

In: Synlett, No. 12, 01.01.1999, p. 1879-1882.

Research output: Contribution to journalArticle

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